Simulation scenario 6, HS phase

Setting description

Several treatments more effective in distinctive signatures: (TC2, TEfus+); (TC3, HRD+); (TC4,PI3K )

Simulations setting

Survival curves (by signature)

PFS distributions (by signature)

Treatment effects (by signature)

signature	var	Other	TC1	TC2	TC3	TC4
all	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.026, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.025, shape = 1.3
all	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 35.8, median = 29.3	mean = 32, median = 26.2	mean = 36.8, median = 30.1
all	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.92, hr = 1.12	af = 0.82, hr = 1.29	af = 0.94, hr = 1.08
HRD+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.024, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.028, shape = 1.3
HRD+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 37.9, median = 31	mean = 78.1, median = 63.8	mean = 32.9, median = 26.9
HRD+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.97, hr = 1.04	af = 2, hr = 0.41	af = 0.84, hr = 1.25
TP53+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.025, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.023, shape = 1.3
TP53+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 37.2, median = 30.4	mean = 30.2, median = 24.7	mean = 39.4, median = 32.2
TP53+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.95, hr = 1.07	af = 0.77, hr = 1.4	af = 1.01, hr = 0.99
TEfus+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.028, shape = 1.3	scale = 0.021, shape = 1.3
TEfus+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 72.6, median = 59.3	mean = 32.8, median = 26.8	mean = 43.2, median = 35.3
TEfus+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.86, hr = 0.45	af = 0.84, hr = 1.25	af = 1.11, hr = 0.88
PI3K+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.023, shape = 1.3	scale = 0.03, shape = 1.3	scale = 0.012, shape = 1.3
PI3K+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 40.6, median = 33.2	mean = 30.7, median = 25.1	mean = 78.4, median = 64
PI3K+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.04, hr = 0.95	af = 0.79, hr = 1.36	af = 2.01, hr = 0.4

Survival curves (by subgroup)

PFS distributions (by subgroup)

Treatment effects (by subgroup)

subtype	var	Other	TC1	TC2	TC3	TC4
—-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
—-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 29.4, median = 24
—-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
—+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
—+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 78.1, median = 63.8
—+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 2, hr = 0.41
–+-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
–+-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 78.1, median = 63.8	mean = 29.4, median = 24	mean = 29.4, median = 24
–+-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 2, hr = 0.41	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
–++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
–++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 29.4, median = 24	mean = 78.1, median = 63.8
–++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 0.75, hr = 1.44	af = 2, hr = 0.41
-+–	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
-+–	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 29.4, median = 24
-+–	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
-+-+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
-+-+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 29.4, median = 24	mean = 78.1, median = 63.8
-+-+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44	af = 2, hr = 0.41
-++-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.031, shape = 1.3
-++-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 78.1, median = 63.8	mean = 29.4, median = 24	mean = 29.4, median = 24
-++-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 2, hr = 0.41	af = 0.75, hr = 1.44	af = 0.75, hr = 1.44
-+++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3
-+++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 29.4, median = 24	mean = 79.9, median = 65.3
-+++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 0.75, hr = 1.44	af = 2.05, hr = 0.39
+—	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+—	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+—	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 0.75, hr = 1.44
+–+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
+–+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
+–+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 2, hr = 0.41
+-+-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+-+-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+-+-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 0.75, hr = 1.44
+-++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
+-++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
+-++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 2, hr = 0.41
++–	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
++–	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 29.4, median = 24
++–	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 0.75, hr = 1.44
++-+	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.031, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
++-+	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 29.4, median = 24	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
++-+	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 0.75, hr = 1.44	af = 2, hr = 0.41	af = 2, hr = 0.41
+++-	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.031, shape = 1.3
+++-	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 29.4, median = 24
+++-	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 0.75, hr = 1.44
++++	param	scale = 0.024, shape = 1.3	scale = 0.029, shape = 1.3	scale = 0.013, shape = 1.3	scale = 0.012, shape = 1.3	scale = 0.012, shape = 1.3
++++	summary	mean = 39, median = 31.9	mean = 31.9, median = 26.1	mean = 70.5, median = 57.5	mean = 78.1, median = 63.8	mean = 78.1, median = 63.8
++++	effect	af = 1, hr = 1	af = 0.82, hr = 1.3	af = 1.8, hr = 0.46	af = 2, hr = 0.41	af = 2, hr = 0.41

Errors and power

graduation (counts and proportions):

TC1 TC2 TC3 TC4 all 4 13 11 34 HRD+ 1 9 332 0 TP53+ 5 22 1 30 TEfus+ 0 320 0 10 PI3K+ 0 10 0 362

TC1 TC2 TC3 TC4 all 0.008 0.026 0.022 0.068 HRD+ 0.002 0.018 0.664 0.000 TP53+ 0.010 0.044 0.002 0.060 TEfus+ 0.000 0.640 0.000 0.020 PI3K+ 0.000 0.020 0.000 0.724

futility (counts and proportions):

TC1 TC2 TC3 TC4 all 50 2 2 0 HRD+ 13 4 0 1 TP53+ 211 11 134 5 TEfus+ 265 0 49 3 PI3K+ 209 8 85 0

TC1 TC2 TC3 TC4 all 0.100 0.004 0.004 0.000 HRD+ 0.026 0.008 0.000 0.002 TP53+ 0.422 0.022 0.268 0.010 TEfus+ 0.530 0.000 0.098 0.006 PI3K+ 0.418 0.016 0.170 0.000

max sample size (counts and proportions):

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

TC1 TC2 TC3 TC4 all 0 0 0 0 HRD+ 0 0 0 0 TP53+ 0 0 0 0 TEfus+ 0 0 0 0 PI3K+ 0 0 0 0

Operating characteristics

Characteristics	Overall	TC1	TC2	TC3	TC4
Error signature	0.172	0.02	0.052	0.024	0.086
Error subgroup	0.264	0.02	0.106	0.024	0.144
Power signature	0.958	0.00	0.640	0.664	0.724
Power subgroup	0.978	0.00	0.692	0.688	0.810

Median results at the end of the trial

By signature:

signature	var	Control	TC1	TC2	TC3	TC4
all	graduation	0	4	13	11	34
all	futility	0	50	2	2	0
all	max_n	0	0	0	0	0
all	n	651 (605, 699)	274 (168, 397)	296 (194, 411)	267 (188, 386)	276 (165, 391)
all	n_unique	651 (605, 699)	274 (168, 397)	296 (194, 411)	267 (188, 386)	276 (165, 391)
all	time_trial	60 (60, 60)	60 (57, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
all	time_stop	NA (NA, NA)	46 (19, 56)	12 (8, 19)	13 (11, 18)	12 (10, 17)
all	post_p	NA (NA, NA)	0.04 (0, 0.28)	0.95 (0.58, 1)	0.47 (0.11, 0.89)	0.99 (0.83, 1)
all	rate	0.023 (0.021, 0.024)	0.028 (0.025, 0.031)	0.02 (0.017, 0.023)	0.024 (0.021, 0.026)	0.019 (0.016, 0.021)
HRD+	graduation	0	1	9	332	0
HRD+	futility	0	13	4	0	1
HRD+	max_n	0	0	0	0	0
HRD+	n	87 (73, 103)	34 (22, 52)	38 (22, 57)	54 (50, 78)	34 (18, 52)
HRD+	n_unique	87 (73, 103)	34 (22, 52)	38 (22, 57)	54 (50, 78)	34 (18, 52)
HRD+	time_trial	60 (60, 60)	60 (60, 60)	60 (60, 60)	49 (38, 60)	60 (60, 60)
HRD+	time_stop	NA (NA, NA)	57 (51, 60)	53 (48, 58)	44 (37, 54)	60 (60, 60)
HRD+	post_p	NA (NA, NA)	0.19 (0.02, 0.58)	0.67 (0.25, 0.95)	1 (0.98, 1)	0.4 (0.08, 0.81)
HRD+	rate	0.022 (0.018, 0.026)	0.028 (0.021, 0.038)	0.019 (0.014, 0.026)	0.009 (0.006, 0.012)	0.024 (0.017, 0.032)
TP53+	graduation	0	5	22	1	30
TP53+	futility	0	211	11	134	5
TP53+	max_n	0	0	0	0	0
TP53+	n	241 (216, 263)	93 (52, 152)	122 (71, 177)	89 (51, 150)	108 (53, 167)
TP53+	n_unique	241 (216, 263)	93 (52, 152)	122 (71, 177)	89 (51, 150)	108 (53, 167)
TP53+	time_trial	60 (60, 60)	60 (34, 60)	60 (60, 60)	60 (36, 60)	60 (60, 60)
TP53+	time_stop	NA (NA, NA)	42 (29, 54)	31 (24, 51)	38 (28, 53)	29 (21, 43)
TP53+	post_p	NA (NA, NA)	0.13 (0.01, 0.48)	0.9 (0.46, 1)	0.11 (0.01, 0.48)	0.96 (0.66, 1)
TP53+	rate	0.022 (0.02, 0.025)	0.028 (0.024, 0.033)	0.019 (0.015, 0.023)	0.028 (0.024, 0.034)	0.017 (0.013, 0.021)
TEfus+	graduation	0	0	320	0	10
TEfus+	futility	0	265	0	49	3
TEfus+	max_n	0	0	0	0	0
TEfus+	n	208 (182, 233)	61 (48, 105)	120 (56, 187)	78 (52, 128)	90 (53, 142)
TEfus+	n_unique	208 (182, 233)	61 (48, 105)	120 (56, 187)	78 (52, 128)	90 (53, 142)
TEfus+	time_trial	60 (60, 60)	58 (36, 60)	49 (27, 60)	60 (60, 60)	60 (60, 60)
TEfus+	time_stop	NA (NA, NA)	46 (33, 57)	39 (26, 56)	40 (28, 54)	28 (22, 41)
TEfus+	post_p	NA (NA, NA)	0.01 (0, 0.14)	1 (0.98, 1)	0.14 (0.01, 0.59)	0.85 (0.42, 0.99)
TEfus+	rate	0.018 (0.016, 0.02)	0.028 (0.023, 0.034)	0.01 (0.008, 0.012)	0.022 (0.018, 0.027)	0.015 (0.012, 0.018)
PI3K+	graduation	0	0	10	0	362
PI3K+	futility	0	209	8	85	0
PI3K+	max_n	0	0	0	0	0
PI3K+	n	224 (198, 249)	76 (50, 129)	110 (60, 164)	81 (50, 138)	108 (54, 195)
PI3K+	n_unique	224 (198, 249)	76 (50, 129)	110 (60, 164)	81 (50, 138)	108 (54, 195)
PI3K+	time_trial	60 (60, 60)	60 (37, 60)	60 (60, 60)	60 (43, 60)	42 (26, 60)
PI3K+	time_stop	NA (NA, NA)	44 (32, 55)	32 (23, 53)	40 (29, 54)	36 (25, 52)
PI3K+	post_p	NA (NA, NA)	0.08 (0, 0.39)	0.92 (0.59, 1)	0.12 (0.01, 0.49)	1 (1, 1)
PI3K+	rate	0.022 (0.019, 0.024)	0.028 (0.023, 0.034)	0.017 (0.014, 0.021)	0.027 (0.022, 0.032)	0.009 (0.007, 0.011)

By subgroup combinations:

subtype	var	Control	TC1	TC2	TC3	TC4
—-	graduation	0	4	13	11	34
—-	futility	0	50	2	2	0
—-	max_n	0	0	0	0	0
—-	n	205 (173, 232)	96 (28, 206)	58 (23, 165)	66 (21, 173)	59 (18, 158)
—-	n_unique	205 (173, 232)	96 (28, 206)	58 (23, 165)	66 (21, 173)	59 (18, 158)
—-	post_p	NA (NA, NA)	0.35 (0.05, 0.81)	0.19 (0.03, 0.62)	0.18 (0.03, 0.66)	0.19 (0.02, 0.61)
—-	rate	0.025 (0.022, 0.029)	0.028 (0.023, 0.037)	0.031 (0.025, 0.041)	0.031 (0.025, 0.041)	0.031 (0.025, 0.043)
—+	graduation	0	4	23	11	395
—+	futility	0	226	10	87	0
—+	max_n	0	0	0	0	0
—+	n	47 (36, 57)	17 (8, 39)	16 (7, 38)	15 (7, 36)	24 (9, 46)
—+	n_unique	47 (36, 57)	17 (8, 39)	16 (7, 38)	15 (7, 36)	24 (9, 46)
—+	post_p	NA (NA, NA)	0.36 (0.08, 0.74)	0.3 (0.07, 0.68)	0.3 (0.09, 0.7)	0.99 (0.9, 1)
—+	rate	0.026 (0.02, 0.032)	0.029 (0.02, 0.047)	0.03 (0.021, 0.054)	0.031 (0.021, 0.047)	0.009 (0.005, 0.015)
–+-	graduation	0	4	333	11	44
–+-	futility	0	287	2	51	3
–+-	max_n	0	0	0	0	0
–+-	n	13 (8, 18)	6 (3, 11)	7 (3, 15)	6 (3, 13)	6 (2, 11)
–+-	n_unique	13 (8, 18)	6 (3, 11)	7 (3, 15)	6 (3, 13)	6 (2, 11)
–+-	post_p	NA (NA, NA)	0.36 (0.12, 0.66)	0.78 (0.5, 0.94)	0.34 (0.1, 0.65)	0.34 (0.12, 0.59)
–+-	rate	0.018 (0.009, 0.03)	0.029 (0.014, 0.064)	0.009 (0, 0.02)	0.03 (0.013, 0.063)	0.032 (0.016, 0.07)
–++	graduation	0	4	336	11	398
–++	futility	0	359	10	125	3
–++	max_n	0	0	0	0	0
–++	n	69 (53, 83)	16 (9, 40)	36 (17, 68)	17 (8, 46)	29 (14, 65)
–++	n_unique	69 (53, 83)	16 (9, 40)	36 (17, 68)	17 (8, 46)	29 (14, 65)
–++	post_p	NA (NA, NA)	0.11 (0.01, 0.4)	0.95 (0.66, 1)	0.08 (0.01, 0.3)	0.97 (0.74, 1)
–++	rate	0.018 (0.014, 0.023)	0.03 (0.02, 0.046)	0.01 (0.007, 0.015)	0.031 (0.022, 0.049)	0.009 (0.006, 0.014)
-+–	graduation	0	9	35	12	64
-+–	futility	0	219	13	136	5
-+–	max_n	0	0	0	0	0
-+–	n	84 (68, 102)	34 (13, 75)	31 (15, 73)	29 (11, 69)	30 (10, 70)
-+–	n_unique	84 (68, 102)	34 (13, 75)	31 (15, 73)	29 (11, 69)	30 (10, 70)
-+–	post_p	NA (NA, NA)	0.38 (0.1, 0.81)	0.3 (0.05, 0.73)	0.3 (0.06, 0.75)	0.31 (0.05, 0.77)
-+–	rate	0.025 (0.021, 0.031)	0.029 (0.022, 0.041)	0.031 (0.024, 0.044)	0.031 (0.023, 0.044)	0.03 (0.022, 0.048)
-+-+	graduation	0	7	44	11	403
-+-+	futility	0	303	19	161	3
-+-+	max_n	0	0	0	0	0
-+-+	n	57 (45, 69)	18 (8, 46)	20 (9, 43)	17 (7, 45)	28 (12, 55)
-+-+	n_unique	57 (45, 69)	18 (8, 46)	20 (9, 43)	17 (7, 45)	28 (12, 55)
-+-+	post_p	NA (NA, NA)	0.39 (0.09, 0.8)	0.3 (0.06, 0.7)	0.28 (0.06, 0.7)	1 (0.93, 1)
-+-+	rate	0.025 (0.02, 0.032)	0.028 (0.019, 0.044)	0.031 (0.022, 0.047)	0.032 (0.021, 0.047)	0.009 (0.006, 0.014)
-++-	graduation	0	7	337	11	71
-++-	futility	0	375	10	173	8
-++-	max_n	0	0	0	0	0
-++-	n	52 (41, 63)	13 (6, 31)	33 (15, 57)	14 (7, 37)	14 (6, 40)
-++-	n_unique	52 (41, 63)	13 (6, 31)	33 (15, 57)	14 (7, 37)	14 (6, 40)
-++-	post_p	NA (NA, NA)	0.18 (0.03, 0.53)	0.98 (0.83, 1)	0.13 (0.02, 0.46)	0.15 (0.02, 0.42)
-++-	rate	0.018 (0.013, 0.023)	0.029 (0.02, 0.045)	0.009 (0.005, 0.013)	0.031 (0.021, 0.051)	0.031 (0.021, 0.053)
-+++	graduation	0	7	340	11	404
-+++	futility	0	404	16	195	6
-+++	max_n	0	0	0	0	0
-+++	n	38 (26, 48)	11 (6, 24)	20 (8, 39)	12 (6, 29)	17 (7, 34)
-+++	n_unique	38 (26, 48)	11 (6, 24)	20 (8, 39)	12 (6, 29)	17 (7, 34)
-+++	post_p	NA (NA, NA)	0.18 (0.04, 0.5)	0.86 (0.5, 0.98)	0.14 (0.02, 0.41)	0.91 (0.65, 0.99)
-+++	rate	0.018 (0.013, 0.025)	0.029 (0.019, 0.048)	0.01 (0.006, 0.018)	0.031 (0.02, 0.048)	0.009 (0.004, 0.015)
+—	graduation	0	5	22	343	34
+—	futility	0	63	6	2	1
+—	max_n	0	0	0	0	0
+—	n	42 (33, 53)	15 (7, 30)	14 (6, 27)	30 (21, 45)	13 (5, 28)
+—	n_unique	42 (33, 53)	15 (7, 30)	14 (6, 27)	30 (21, 45)	13 (5, 28)
+—	post_p	NA (NA, NA)	0.38 (0.08, 0.78)	0.32 (0.07, 0.71)	1 (0.94, 1)	0.31 (0.08, 0.7)
+—	rate	0.026 (0.019, 0.033)	0.028 (0.018, 0.051)	0.031 (0.02, 0.05)	0.009 (0.005, 0.013)	0.032 (0.02, 0.053)
+–+	graduation	0	5	32	325	395
+–+	futility	0	231	13	58	1
+–+	max_n	0	0	0	0	0
+–+	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+–+	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
+–+	rate	0.039 (0, 0.084)	0.081 (0.081, 0.081)	0.063 (0, 1.075)	0.091 (0.066, 0.116)	0 (0, 0)
+-+-	graduation	0	4	337	342	44
+-+-	futility	0	293	6	41	4
+-+-	max_n	0	0	0	0	0
+-+-	n	30 (22, 38)	9 (5, 18)	13 (5, 25)	18 (10, 28)	10 (4, 22)
+-+-	n_unique	30 (22, 38)	9 (5, 18)	13 (5, 25)	18 (10, 28)	10 (4, 22)
+-+-	post_p	NA (NA, NA)	0.21 (0.04, 0.54)	0.8 (0.47, 0.96)	0.88 (0.57, 0.98)	0.18 (0.04, 0.47)
+-+-	rate	0.018 (0.012, 0.025)	0.03 (0.017, 0.054)	0.01 (0.004, 0.019)	0.009 (0.005, 0.016)	0.032 (0.019, 0.055)
+-++	graduation	0	4	340	324	398
+-++	futility	0	361	13	87	4
+-++	max_n	0	0	0	0	0
+-++	n	6 (2, 10)	3 (1, 6)	3 (0, 6)	3 (1, 7)	3 (0, 6)
+-++	n_unique	6 (2, 10)	3 (1, 6)	3 (0, 6)	3 (1, 7)	3 (0, 6)
+-++	post_p	NA (NA, NA)	0.42 (0.27, 0.56)	0.53 (0.42, 0.67)	0.54 (0.41, 0.71)	0.53 (0.42, 0.67)
+-++	rate	0.016 (0, 0.039)	0.028 (0.007, 0.076)	0.009 (0, 0.034)	0.009 (0, 0.031)	0.009 (0, 0.027)
++–	graduation	0	10	44	324	64
++–	futility	0	224	17	75	6
++–	max_n	0	0	0	0	0
++–	n	1 (0, 3)	0 (0, 2)	1 (0, 2)	0 (0, 2)	0 (0, 2)
++–	n_unique	1 (0, 3)	0 (0, 2)	1 (0, 2)	0 (0, 2)	0 (0, 2)
++–	post_p	NA (NA, NA)	0.49 (0.42, 0.57)	0.5 (0.43, 0.57)	0.54 (0.46, 0.59)	0.48 (0.41, 0.57)
++–	rate	0.026 (0, 0.089)	0.028 (0, 0.13)	0.025 (0, 0.108)	0 (0, 0.052)	0.034 (0, 0.155)
++-+	graduation	0	8	53	312	403
++-+	futility	0	306	22	96	4
++-+	max_n	0	0	0	0	0
++-+	n	8 (4, 13)	4 (1, 8)	5 (2, 9)	5 (1, 9)	3 (1, 7)
++-+	n_unique	8 (4, 13)	4 (1, 8)	5 (2, 9)	5 (1, 9)	3 (1, 7)
++-+	post_p	NA (NA, NA)	0.42 (0.22, 0.6)	0.43 (0.22, 0.63)	0.65 (0.45, 0.86)	0.62 (0.42, 0.83)
++-+	rate	0.025 (0.01, 0.045)	0.03 (0.011, 0.073)	0.029 (0.011, 0.063)	0.009 (0, 0.025)	0.009 (0, 0.03)
+++-	graduation	0	7	341	322	71
+++-	futility	0	378	14	104	9
+++-	max_n	0	0	0	0	0
+++-	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
+++-	post_p	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)
+++-	rate	0.105 (0, 0.35)	0 (0, 0.04)	0 (0, 0)	0 (0, 0)	0 (0, 0.07)
++++	graduation	0	7	344	311	404
++++	futility	0	405	19	122	7
++++	max_n	0	0	0	0	0
++++	n	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	n_unique	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
++++	post_p	NA (NA, NA)	0.54 (0.54, 0.54)	0.56 (0.56, 0.56)	NA (NA, NA)	0.49 (0.48, 0.52)
++++	rate	0 (0, 0.251)	0 (0, 0.112)	0 (0, 0.023)	0 (0, 0.021)	0 (0, 0.023)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates

Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:

signature	var	TC1	TC2	TC3	TC4
all	count	4	13	11	34
all	time_stop	12 (10, 15)	14 (10, 19)	12 (11, 17)	12 (10, 17)
all	n_trt	77 (67, 101)	93 (68, 137)	65 (51, 79)	62 (52, 90)
all	n_control	104 (95, 130)	119 (84, 159)	102 (94, 135)	96 (79, 138)
all	post_p	0.95 (0.89, 0.98)	0.92 (0.87, 0.98)	0.94 (0.88, 0.99)	0.92 (0.88, 0.97)
all	order	1 (1, 1)	1 (1, 1)	1 (1, 1)	1 (1, 1)
HRD+	count	1	9	332
HRD+	time_stop	47 (47, 47)	53 (50, 58)	44 (37, 54)
HRD+	n_trt	53 (53, 53)	51 (50, 53)	52 (50, 65)
HRD+	n_control	79 (79, 79)	74 (55, 84)	60 (44, 77)
HRD+	post_p	0.93 (0.93, 0.93)	0.98 (0.95, 1)	1 (0.96, 1)
HRD+	order	2 (2, 2)	2 (1.8, 3.4)	2 (1, 3)
TP53+	count	5	22	1	30
TP53+	time_stop	26 (23, 29)	31 (24, 48)	19 (19, 19)	30 (21, 44)
TP53+	n_trt	54 (51, 57)	90 (63, 143)	51 (51, 51)	63 (51, 118)
TP53+	n_control	75 (71, 87)	106 (71, 170)	62 (62, 62)	98 (58, 165)
TP53+	post_p	0.91 (0.9, 0.94)	0.99 (0.9, 1)	0.98 (0.98, 0.98)	0.98 (0.95, 1)
TP53+	order	1 (1, 1.6)	2 (1, 3)	1 (1, 1)	2 (1, 3.1)
TEfus+	count		320		10
TEfus+	time_stop		39 (26, 56)		27 (22, 36)
TEfus+	n_trt		96 (56, 164)		54 (51, 65)
TEfus+	n_control		116 (70, 190)		71 (60, 93)
TEfus+	post_p		1 (0.95, 1)		0.96 (0.93, 0.98)
TEfus+	order		2 (1, 3)		1 (1, 2)
PI3K+	count		10		362
PI3K+	time_stop		37 (28, 54)		36 (25, 52)
PI3K+	n_trt		74 (60, 113)		98 (60, 161)
PI3K+	n_control		114 (83, 205)		112 (67, 183)
PI3K+	post_p		1 (0.93, 1)		1 (0.99, 1)
PI3K+	order		2 (1, 3.1)		1 (1, 3)

Futility:

signature	var	TC1	TC2	TC3	TC4
all	count	50	2	2
all	time_stop	46 (27, 56)	8 (8, 8)	18 (17, 18)
all	n_trt	175 (120, 290)	57 (57, 57)	82 (74, 91)
all	n_control	470 (242, 610)	63 (60, 66)	143 (143, 143)
all	post_p	0 (0, 0.02)	0.24 (0.2, 0.29)	0.05 (0.03, 0.08)
all	order	2.5 (1, 5)	1 (1, 1)	1 (1, 1)
HRD+	count	13	4		1
HRD+	time_stop	58 (51, 60)	52 (49, 56)		60 (60, 60)
HRD+	n_trt	53 (51, 61)	58 (54, 63)		51 (51, 51)
HRD+	n_control	84 (78, 103)	74 (72, 88)		89 (89, 89)
HRD+	post_p	0.1 (0.01, 0.17)	0.28 (0.16, 0.3)		0.04 (0.04, 0.04)
HRD+	order	3 (1, 4)	3 (2.3, 4.4)		1 (1, 1)
TP53+	count	211	11	134	5
TP53+	time_stop	42 (30, 54)	31 (26, 52)	38 (28, 53)	26 (21, 29)
TP53+	n_trt	69 (51, 116)	65 (57, 84)	63 (50, 100)	52 (50, 63)
TP53+	n_control	157 (93, 214)	114 (67, 200)	135 (90, 197)	90 (56, 108)
TP53+	post_p	0.08 (0.01, 0.21)	0.18 (0.05, 0.26)	0.09 (0.01, 0.21)	0.15 (0.04, 0.3)
TP53+	order	2 (1, 3)	1 (1, 4)	1 (1, 3)	1 (1, 1)
TEfus+	count	265		49	3
TEfus+	time_stop	46 (33, 57)		40 (28, 54)	39 (23, 46)
TEfus+	n_trt	58 (50, 94)		58 (50, 80)	54 (52, 60)
TEfus+	n_control	141 (90, 202)		113 (68, 187)	132 (62, 166)
TEfus+	post_p	0.02 (0, 0.14)		0.04 (0, 0.21)	0.06 (0.03, 0.16)
TEfus+	order	2 (1, 3)		2 (1, 4)	1 (1, 1.8)
PI3K+	count	209	8	85
PI3K+	time_stop	44 (32, 55)	30 (23, 41)	40 (29, 54)
PI3K+	n_trt	63 (51, 96)	54 (51, 63)	56 (50, 87)
PI3K+	n_control	150 (91, 210)	84 (61, 134)	145 (81, 200)
PI3K+	post_p	0.05 (0.01, 0.19)	0.09 (0.04, 0.29)	0.06 (0.01, 0.19)
PI3K+	order	2 (1, 4)	2 (1, 3)	2 (1, 4)

By subgroup combinations

Graduation:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4	4
all	TC1	time	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)	12 (10, 15)
all	TC1	n	32 (26, 42)	8 (7, 10)	2 (0, 5)	8 (6, 11)	8 (7, 13)	4 (3, 5)	4 (2, 4)	4 (3, 5)	5 (3, 7)	0 (0, 0)	2 (0, 4)	1 (0, 1)	0 (0, 0)	0 (0, 1)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.73 (0.61, 0.92)	0.52 (0.51, 0.57)	0.52 (0.52, 0.52)	0.52 (0.51, 0.56)	0.53 (0.51, 0.55)	0.52 (0.51, 0.53)	0.54 (0.51, 0.55)	0.52 (0.51, 0.54)	0.53 (0.51, 0.55)	NA (NA, NA)	0.51 (0.5, 0.51)	0.52 (0.52, 0.52)	NA (NA, NA)	0.52 (0.51, 0.54)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.007 (0.001, 0.015)	0.014 (0.003, 0.021)	0 (0, 0)	0 (0, 0)	0.007 (0, 0.016)	0 (0, 0)	0 (0, 0)	0 (0, 0.014)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13	13
all	TC2	time	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)	14 (10, 19)
all	TC2	n	27 (21, 46)	3 (1, 10)	1 (0, 5)	12 (4, 16)	17 (11, 19)	8 (5, 12)	8 (5, 13)	6 (3, 12)	3 (1, 6)	0 (0, 0)	2 (1, 6)	0 (0, 1)	0 (0, 0)	0 (0, 2)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.64 (0.56, 0.76)	0.52 (0.51, 0.54)	0.53 (0.51, 0.56)	0.56 (0.51, 0.67)	0.56 (0.52, 0.68)	0.54 (0.52, 0.61)	0.55 (0.52, 0.58)	0.54 (0.5, 0.66)	0.52 (0.5, 0.56)	NA (NA, NA)	0.52 (0.51, 0.54)	0.52 (0.51, 0.52)	NA (NA, NA)	0.53 (0.51, 0.55)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.013 (0.007, 0.018)	0 (0, 0.015)	0 (0, 0.002)	0 (0, 0.005)	0.011 (0, 0.026)	0 (0, 0.018)	0 (0, 0.018)	0 (0, 0)	0 (0, 0.031)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11	11
all	TC3	time	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)	12 (11, 17)
all	TC3	n	16 (12, 20)	4 (0, 6)	1 (0, 2)	6 (3, 8)	7 (5, 15)	4 (2, 6)	4 (2, 6)	3 (2, 5)	11 (7, 13)	0 (0, 0)	4 (2, 6)	1 (0, 2)	0 (0, 1)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.62 (0.52, 0.78)	0.53 (0.52, 0.56)	0.52 (0.5, 0.56)	0.54 (0.51, 0.55)	0.55 (0.5, 0.63)	0.54 (0.51, 0.56)	0.52 (0.5, 0.55)	0.52 (0.5, 0.54)	0.58 (0.52, 0.68)	NA (NA, NA)	0.54 (0.52, 0.56)	0.51 (0.51, 0.53)	NA (NA, NA)	0.53 (0.52, 0.53)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0 (0, 0.024)	0 (0, 0.007)	0 (0, 0)	0 (0, 0)	0 (0, 0.033)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
all	TC4	count	34	34	34	34	34	34	34	34	34	34	34	34	34	34	34	34
all	TC4	time	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)	12 (10, 17)
all	TC4	n	16 (10, 24)	6 (4, 11)	1 (0, 4)	10 (4, 15)	7 (4, 14)	9 (4, 14)	3 (1, 6)	4 (2, 11)	3 (0, 6)	0 (0, 0)	3 (0, 6)	0 (0, 2)	0 (0, 0)	1 (0, 3)	0 (0, 0)	0 (0, 0)
all	TC4	post_p	0.62 (0.53, 0.74)	0.54 (0.51, 0.61)	0.52 (0.51, 0.55)	0.55 (0.52, 0.63)	0.57 (0.52, 0.65)	0.56 (0.51, 0.6)	0.52 (0.5, 0.55)	0.52 (0.5, 0.57)	0.53 (0.51, 0.57)	NA (NA, NA)	0.52 (0.5, 0.56)	0.53 (0.52, 0.56)	NA (NA, NA)	0.53 (0.5, 0.56)	NA (NA, NA)	NA (NA, NA)
all	TC4	r_prob	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
all	TC4	rate	0.008 (0, 0.021)	0 (0, 0.008)	0 (0, 0)	0 (0, 0.015)	0 (0, 0.022)	0 (0, 0.013)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0.008)	NA (NA, NA)	0 (0, 0)
HRD+	TC1	count									1	1	1	1	1	1	1	1
HRD+	TC1	time									47 (47, 47)	47 (47, 47)	47 (47, 47)	47 (47, 47)	47 (47, 47)	47 (47, 47)	47 (47, 47)	47 (47, 47)
HRD+	TC1	n									36 (36, 36)	0 (0, 0)	15 (15, 15)	0 (0, 0)	0 (0, 0)	2 (2, 2)	0 (0, 0)	0 (0, 0)
HRD+	TC1	post_p									0.93 (0.93, 0.93)	NA (NA, NA)	0.71 (0.71, 0.71)	NA (NA, NA)	NA (NA, NA)	0.55 (0.55, 0.55)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.014 (0.014, 0.014)	NA (NA, NA)	0.008 (0.008, 0.008)	NA (NA, NA)	NA (NA, NA)	0.026 (0.026, 0.026)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	count									9	9	9	9	9	9	9	9
HRD+	TC2	time									53 (50, 58)	53 (50, 58)	53 (50, 58)	53 (50, 58)	53 (50, 58)	53 (50, 58)	53 (50, 58)	53 (50, 58)
HRD+	TC2	n									21 (13, 26)	0 (0, 0)	22 (12, 24)	5 (3, 6)	1 (0, 3)	6 (4, 9)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.88 (0.71, 0.98)	NA (NA, NA)	0.82 (0.76, 0.98)	0.56 (0.51, 0.64)	0.53 (0.53, 0.53)	0.56 (0.52, 0.74)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.016 (0.012, 0.02)	NA (NA, NA)	0.007 (0.002, 0.01)	0.008 (0, 0.016)	0.018 (0, 0.034)	0.016 (0.008, 0.023)	NA (NA, NA)	NA (NA, NA)
HRD+	TC3	count									332	332	332	332	332	332	332	332
HRD+	TC3	time									44 (37, 54)	44 (37, 54)	44 (37, 54)	44 (37, 54)	44 (37, 54)	44 (37, 54)	44 (37, 54)	44 (37, 54)
HRD+	TC3	n									28 (21, 37)	0 (0, 0)	18 (10, 24)	3 (1, 7)	0 (0, 2)	4 (1, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC3	post_p									0.97 (0.81, 1)	NA (NA, NA)	0.8 (0.7, 0.95)	0.55 (0.51, 0.64)	0.54 (0.51, 0.57)	0.57 (0.51, 0.73)	0.52 (0.52, 0.52)	NA (NA, NA)
HRD+	TC3	r_prob									0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
HRD+	TC3	rate									0.008 (0.003, 0.014)	0.061 (0.012, 0.11)	0.007 (0.003, 0.013)	0 (0, 0.016)	0 (0, 0.031)	0.005 (0, 0.02)	0 (0, 0)	0 (0, 0.018)
TP53+	TC1	count					5	5	5	5					5	5	5	5
TP53+	TC1	time					26 (23, 29)	26 (23, 29)	26 (23, 29)	26 (23, 29)					26 (23, 29)	26 (23, 29)	26 (23, 29)	26 (23, 29)
TP53+	TC1	n					22 (15, 25)	9 (4, 17)	10 (8, 18)	8 (6, 11)					0 (0, 1)	2 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.75 (0.71, 0.78)	0.54 (0.53, 0.85)	0.62 (0.52, 0.73)	0.57 (0.54, 0.66)					NA (NA, NA)	0.52 (0.51, 0.53)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.015 (0.009, 0.02)	0.006 (0.002, 0.013)	0.009 (0.008, 0.024)	0 (0, 0.012)					0 (0, 0)	0.012 (0, 0.035)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	count					22	22	22	22					22	22	22	22
TP53+	TC2	time					31 (24, 48)	31 (24, 48)	31 (24, 48)	31 (24, 48)					31 (24, 48)	31 (24, 48)	31 (24, 48)	31 (24, 48)
TP53+	TC2	n					32 (18, 42)	18 (10, 34)	22 (15, 37)	15 (7, 28)					0 (0, 1)	3 (0, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.78 (0.71, 0.9)	0.73 (0.54, 0.82)	0.87 (0.74, 0.96)	0.75 (0.57, 0.94)					0.53 (0.53, 0.53)	0.53 (0.5, 0.56)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.018 (0.011, 0.024)	0.016 (0.004, 0.022)	0.006 (0.004, 0.011)	0.005 (0, 0.009)					0.039 (0.012, 0.046)	0.008 (0, 0.038)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					1	1	1	1					1	1	1	1
TP53+	TC3	time					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)					19 (19, 19)	19 (19, 19)	19 (19, 19)	19 (19, 19)
TP53+	TC3	n					16 (16, 16)	13 (13, 13)	8 (8, 8)	9 (9, 9)					2 (2, 2)	3 (3, 3)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.72 (0.72, 0.72)	0.73 (0.73, 0.73)	0.58 (0.58, 0.58)	0.56 (0.56, 0.56)					NA (NA, NA)	0.53 (0.53, 0.53)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0 (0, 0)	0 (0, 0)	0.015 (0.015, 0.015)	0 (0, 0)					0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	count					30	30	30	30					30	30	30	30
TP53+	TC4	time					30 (21, 44)	30 (21, 44)	30 (21, 44)	30 (21, 44)					30 (21, 44)	30 (21, 44)	30 (21, 44)	30 (21, 44)
TP53+	TC4	n					20 (14, 36)	20 (15, 39)	8 (6, 21)	10 (7, 27)					0 (0, 1)	2 (1, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.75 (0.71, 0.86)	0.87 (0.75, 1)	0.56 (0.52, 0.75)	0.71 (0.54, 0.92)					0.54 (0.54, 0.54)	0.53 (0.51, 0.58)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.016 (0.009, 0.023)	0.005 (0, 0.01)	0.013 (0, 0.022)	0.007 (0, 0.016)					0 (0, 0.046)	0 (0, 0.011)	NA (NA, NA)	0 (0, 0)
TEfus+	TC2	count			320	320			320	320			320	320			320	320
TEfus+	TC2	time			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)			39 (26, 56)	39 (26, 56)
TEfus+	TC2	n			6 (3, 12)	31 (17, 56)			26 (15, 46)	18 (8, 31)			10 (5, 22)	3 (0, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	post_p			0.61 (0.52, 0.86)	0.84 (0.71, 0.98)			0.87 (0.72, 0.99)	0.75 (0.56, 0.94)			0.69 (0.52, 0.9)	0.53 (0.51, 0.6)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC2	r_prob			0.41 (0.41, 0.41)	0.27 (0.27, 0.27)			0.41 (0.41, 0.41)	0.25 (0.25, 0.25)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC2	rate			0.006 (0, 0.018)	0.008 (0.003, 0.013)			0.007 (0.002, 0.013)	0.008 (0, 0.014)			0.007 (0, 0.016)	0 (0, 0.019)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	count			10	10			10	10			10	10			10	10
TEfus+	TC4	time			27 (22, 36)	27 (22, 36)			27 (22, 36)	27 (22, 36)			27 (22, 36)	27 (22, 36)			27 (22, 36)	27 (22, 36)
TEfus+	TC4	n			2 (1, 5)	22 (17, 33)			8 (7, 10)	13 (6, 19)			6 (3, 7)	2 (1, 7)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.53 (0.51, 0.55)	0.76 (0.74, 0.93)			0.57 (0.51, 0.65)	0.67 (0.54, 0.89)			0.52 (0.5, 0.56)	0.53 (0.51, 0.59)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0 (0, 0.002)	0.005 (0, 0.009)			0.015 (0, 0.024)	0.004 (0, 0.009)			0.014 (0, 0.021)	0 (0, 0.001)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC2	count		10		10		10		10		10		10		10		10
PI3K+	TC2	time		37 (28, 54)		37 (28, 54)		37 (28, 54)		37 (28, 54)		37 (28, 54)		37 (28, 54)		37 (28, 54)		37 (28, 54)
PI3K+	TC2	n		10 (8, 19)		26 (19, 41)		18 (9, 29)		14 (7, 19)		0 (0, 0)		2 (1, 6)		4 (1, 6)		0 (0, 0)
PI3K+	TC2	post_p		0.69 (0.57, 0.87)		0.85 (0.71, 0.94)		0.73 (0.51, 0.82)		0.82 (0.71, 0.92)		NA (NA, NA)		0.55 (0.51, 0.67)		0.55 (0.51, 0.62)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.012 (0, 0.018)		0.008 (0.004, 0.01)		0.021 (0.013, 0.027)		0.009 (0, 0.011)		NA (NA, NA)		0 (0, 0.008)		0 (0, 0.031)		NA (NA, NA)
PI3K+	TC4	count		362		362		362		362		362		362		362		362
PI3K+	TC4	time		36 (25, 52)		36 (25, 52)		36 (25, 52)		36 (25, 52)		36 (25, 52)		36 (25, 52)		36 (25, 52)		36 (25, 52)
PI3K+	TC4	n		21 (10, 37)		26 (16, 48)		26 (15, 45)		16 (8, 29)		0 (0, 0)		2 (0, 6)		3 (1, 6)		0 (0, 0)
PI3K+	TC4	post_p		0.88 (0.7, 1)		0.84 (0.72, 0.98)		0.93 (0.72, 1)		0.75 (0.55, 0.95)		NA (NA, NA)		0.53 (0.51, 0.6)		0.55 (0.51, 0.66)		0.51 (0.51, 0.51)
PI3K+	TC4	r_prob		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.31 (0.31, 0.31)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC4	rate		0.008 (0, 0.015)		0.007 (0, 0.012)		0.007 (0.002, 0.013)		0.006 (0, 0.013)		NA (NA, NA)		0 (0, 0.018)		0 (0, 0.02)		0 (0, 0)

Futility:

signature	treatment	var	—-	—+	–+-	–++	-+–	-+-+	-++-	-+++	+—	+–+	+-+-	+-++	++–	++-+	+++-	++++
all	TC1	count	50	50	50	50	50	50	50	50	50	50	50	50	50	50	50	50
all	TC1	time	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)	46 (27, 56)
all	TC1	n	46 (25, 140)	12 (7, 26)	4 (2, 7)	14 (7, 18)	22 (9, 52)	14 (7, 36)	10 (6, 22)	8 (5, 16)	10 (4, 17)	0 (0, 0)	8 (4, 12)	2 (0, 4)	0 (0, 1)	2 (1, 5)	0 (0, 0)	0 (0, 0)
all	TC1	post_p	0.28 (0.04, 0.45)	0.34 (0.08, 0.45)	0.4 (0.14, 0.49)	0.16 (0.03, 0.47)	0.3 (0.09, 0.44)	0.32 (0.12, 0.46)	0.24 (0.06, 0.45)	0.27 (0.07, 0.45)	0.34 (0.15, 0.47)	NA (NA, NA)	0.25 (0.06, 0.45)	0.43 (0.33, 0.5)	0.44 (0.42, 0.46)	0.44 (0.27, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC1	r_prob	0.37 (0.37, 0.37)	0.27 (0.27, 0.27)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC1	rate	0.029 (0.024, 0.04)	0.029 (0.022, 0.049)	0.036 (0.012, 0.099)	0.03 (0.016, 0.045)	0.032 (0.024, 0.048)	0.029 (0.018, 0.043)	0.027 (0.02, 0.046)	0.026 (0.017, 0.052)	0.031 (0.021, 0.05)	NA (NA, NA)	0.032 (0.021, 0.056)	0.035 (0, 0.09)	0.035 (0, 0.108)	0.041 (0.014, 0.16)	NA (NA, NA)	NA (NA, NA)
all	TC2	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC2	time	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)	8 (8, 8)
all	TC2	n	14 (12, 16)	1 (0, 2)	2 (2, 2)	7 (7, 7)	10 (10, 10)	7 (5, 9)	5 (4, 6)	4 (3, 6)	2 (2, 2)	0 (0, 0)	4 (2, 5)	0 (0, 1)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	post_p	0.42 (0.37, 0.47)	0.43 (0.43, 0.43)	0.49 (0.49, 0.49)	0.49 (0.49, 0.5)	0.37 (0.35, 0.38)	0.45 (0.44, 0.46)	0.48 (0.48, 0.48)	0.48 (0.48, 0.48)	0.49 (0.48, 0.49)	NA (NA, NA)	0.48 (0.48, 0.48)	0.5 (0.5, 0.5)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC2	r_prob	0.25 (0.25, 0.25)	0.07 (0.07, 0.07)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
all	TC2	rate	0.039 (0.027, 0.051)	0.182 (0.182, 0.182)	0 (0, 0)	0.017 (0.003, 0.031)	0.04 (0.04, 0.041)	0.032 (0.024, 0.041)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)	NA (NA, NA)
all	TC3	count	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2	2
all	TC3	time	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)	18 (17, 18)
all	TC3	n	19 (14, 24)	6 (6, 7)	0 (0, 1)	9 (7, 11)	8 (6, 9)	4 (3, 5)	6 (4, 8)	4 (3, 4)	12 (10, 14)	0 (0, 0)	8 (8, 9)	2 (1, 4)	0 (0, 1)	4 (2, 5)	0 (0, 0)	0 (0, 0)
all	TC3	post_p	0.26 (0.23, 0.3)	0.37 (0.36, 0.38)	0.48 (0.48, 0.48)	0.35 (0.31, 0.39)	0.49 (0.48, 0.5)	0.44 (0.43, 0.44)	0.46 (0.46, 0.46)	0.44 (0.42, 0.47)	0.48 (0.46, 0.49)	NA (NA, NA)	0.43 (0.38, 0.48)	NA (NA, NA)	NA (NA, NA)	0.49 (0.49, 0.49)	NA (NA, NA)	NA (NA, NA)
all	TC3	r_prob	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
all	TC3	rate	0.039 (0.038, 0.039)	0.041 (0.035, 0.046)	0 (0, 0)	0.049 (0.033, 0.065)	0.021 (0.016, 0.025)	0.087 (0.039, 0.136)	0.025 (0.017, 0.033)	0.019 (0.004, 0.034)	0.012 (0.011, 0.013)	NA (NA, NA)	0.015 (0.013, 0.018)	0 (0, 0)	0 (0, 0)	0 (0, 0)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	count									13	13	13	13	13	13	13	13
HRD+	TC1	time									58 (51, 60)	58 (51, 60)	58 (51, 60)	58 (51, 60)	58 (51, 60)	58 (51, 60)	58 (51, 60)	58 (51, 60)
HRD+	TC1	n									26 (10, 37)	0 (0, 0)	14 (8, 35)	5 (2, 8)	0 (0, 2)	3 (3, 8)	0 (0, 0)	0 (0, 1)
HRD+	TC1	post_p									0.39 (0.05, 0.49)	NA (NA, NA)	0.19 (0.05, 0.39)	0.44 (0.33, 0.49)	0.45 (0.42, 0.49)	0.4 (0.15, 0.47)	NA (NA, NA)	NA (NA, NA)
HRD+	TC1	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC1	rate									0.025 (0.02, 0.038)	NA (NA, NA)	0.028 (0.022, 0.039)	0.028 (0.017, 0.038)	0.037 (0.013, 0.136)	0.041 (0.023, 0.081)	NA (NA, NA)	0.019 (0.004, 0.035)
HRD+	TC2	count									4	4	4	4	4	4	4	4
HRD+	TC2	time									52 (49, 56)	52 (49, 56)	52 (49, 56)	52 (49, 56)	52 (49, 56)	52 (49, 56)	52 (49, 56)	52 (49, 56)
HRD+	TC2	n									32 (21, 37)	0 (0, 0)	18 (16, 27)	2 (0, 5)	1 (0, 3)	2 (1, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC2	post_p									0.44 (0.31, 0.47)	NA (NA, NA)	0.39 (0.23, 0.46)	0.41 (0.39, 0.48)	0.44 (0.44, 0.44)	0.43 (0.38, 0.44)	NA (NA, NA)	NA (NA, NA)
HRD+	TC2	r_prob									0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
HRD+	TC2	rate									0.025 (0.022, 0.029)	NA (NA, NA)	0.019 (0.013, 0.026)	0.036 (0.015, 0.164)	0.083 (0.074, 0.091)	0.175 (0.032, 0.43)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	count									1	1	1	1	1	1	1	1
HRD+	TC4	time									60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)	60 (60, 60)
HRD+	TC4	n									24 (24, 24)	0 (0, 0)	14 (14, 14)	5 (5, 5)	0 (0, 0)	8 (8, 8)	0 (0, 0)	0 (0, 0)
HRD+	TC4	post_p									0.39 (0.39, 0.39)	NA (NA, NA)	0.01 (0.01, 0.01)	0.46 (0.46, 0.46)	NA (NA, NA)	0.23 (0.23, 0.23)	NA (NA, NA)	NA (NA, NA)
HRD+	TC4	r_prob									0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
HRD+	TC4	rate									0.028 (0.028, 0.028)	NA (NA, NA)	0.043 (0.043, 0.043)	0.009 (0.009, 0.009)	NA (NA, NA)	0.035 (0.035, 0.035)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	count					211	211	211	211					211	211	211	211
TP53+	TC1	time					42 (30, 54)	42 (30, 54)	42 (30, 54)	42 (30, 54)					42 (30, 54)	42 (30, 54)	42 (30, 54)	42 (30, 54)
TP53+	TC1	n					26 (13, 55)	14 (8, 32)	12 (6, 25)	9 (6, 17)					0 (0, 2)	3 (1, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC1	post_p					0.36 (0.13, 0.48)	0.31 (0.11, 0.47)	0.28 (0.07, 0.45)	0.28 (0.07, 0.46)					0.46 (0.42, 0.49)	0.45 (0.29, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC1	r_prob					0.18 (0.18, 0.18)	0.07 (0.07, 0.07)	0.12 (0.12, 0.12)	0.06 (0.06, 0.06)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC1	rate					0.029 (0.023, 0.04)	0.03 (0.021, 0.044)	0.027 (0.019, 0.044)	0.028 (0.018, 0.047)					0.03 (0, 0.15)	0.032 (0.008, 0.086)	0 (0, 0)	0 (0, 0.341)
TP53+	TC2	count					11	11	11	11					11	11	11	11
TP53+	TC2	time					31 (26, 52)	31 (26, 52)	31 (26, 52)	31 (26, 52)					31 (26, 52)	31 (26, 52)	31 (26, 52)	31 (26, 52)
TP53+	TC2	n					21 (11, 28)	15 (9, 18)	16 (13, 30)	10 (7, 19)					0 (0, 1)	3 (2, 5)	0 (0, 0)	0 (0, 0)
TP53+	TC2	post_p					0.27 (0.08, 0.48)	0.29 (0.13, 0.48)	0.44 (0.38, 0.5)	0.42 (0.33, 0.47)					0.49 (0.49, 0.49)	0.43 (0.32, 0.46)	NA (NA, NA)	NA (NA, NA)
TP53+	TC2	r_prob					0.41 (0.41, 0.41)	0.27 (0.27, 0.27)	0.41 (0.41, 0.41)	0.25 (0.25, 0.25)					0 (0, 0)	0 (0, 0)	0 (0, 0)	0 (0, 0)
TP53+	TC2	rate					0.029 (0.025, 0.052)	0.029 (0.017, 0.042)	0.017 (0.014, 0.02)	0.018 (0.013, 0.029)					0 (0, 0)	0.029 (0.015, 0.113)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	count					134	134	134	134					134	134	134	134
TP53+	TC3	time					38 (28, 53)	38 (28, 53)	38 (28, 53)	38 (28, 53)					38 (28, 53)	38 (28, 53)	38 (28, 53)	38 (28, 53)
TP53+	TC3	n					24 (12, 43)	12 (7, 28)	12 (6, 25)	10 (6, 21)					0 (0, 2)	3 (0, 6)	0 (0, 0)	0 (0, 0)
TP53+	TC3	post_p					0.38 (0.07, 0.48)	0.32 (0.1, 0.46)	0.27 (0.06, 0.46)	0.27 (0.08, 0.45)					0.48 (0.44, 0.49)	0.47 (0.41, 0.5)	NA (NA, NA)	NA (NA, NA)
TP53+	TC3	r_prob					0 (0, 0)	0 (0, 0)	0.06 (0.06, 0.06)	0.06 (0.06, 0.06)					0.5 (0.5, 0.5)	0.33 (0.33, 0.33)	0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TP53+	TC3	rate					0.029 (0.022, 0.043)	0.03 (0.022, 0.055)	0.029 (0.018, 0.056)	0.026 (0.018, 0.049)					0 (0, 0.085)	0.018 (0, 0.049)	0 (0, 0)	0 (0, 0)
TP53+	TC4	count					5	5	5	5					5	5	5	5
TP53+	TC4	time					26 (21, 29)	26 (21, 29)	26 (21, 29)	26 (21, 29)					26 (21, 29)	26 (21, 29)	26 (21, 29)	26 (21, 29)
TP53+	TC4	n					19 (14, 29)	13 (10, 16)	8 (6, 11)	11 (8, 13)					0 (0, 2)	2 (0, 4)	0 (0, 0)	0 (0, 0)
TP53+	TC4	post_p					0.34 (0.16, 0.46)	0.48 (0.27, 0.49)	0.35 (0.16, 0.42)	0.44 (0.31, 0.48)					NA (NA, NA)	0.47 (0.45, 0.49)	NA (NA, NA)	NA (NA, NA)
TP53+	TC4	r_prob					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.31 (0.31, 0.31)					0 (0, 0)	0.33 (0.33, 0.33)	0 (0, 0)	0.33 (0.33, 0.33)
TP53+	TC4	rate					0.029 (0.024, 0.034)	0.017 (0.01, 0.035)	0.038 (0.017, 0.055)	0.022 (0.014, 0.028)					0 (0, 0)	0.033 (0.009, 0.04)	NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	count			265	265			265	265			265	265			265	265
TEfus+	TC1	time			46 (33, 57)	46 (33, 57)			46 (33, 57)	46 (33, 57)			46 (33, 57)	46 (33, 57)			46 (33, 57)	46 (33, 57)
TEfus+	TC1	n			5 (2, 10)	16 (9, 34)			13 (7, 28)	11 (6, 22)			9 (5, 14)	3 (1, 6)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	post_p			0.41 (0.17, 0.49)	0.17 (0.02, 0.43)			0.3 (0.07, 0.47)	0.27 (0.07, 0.47)			0.32 (0.08, 0.47)	0.44 (0.33, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC1	r_prob			0.18 (0.18, 0.18)	0.07 (0.07, 0.07)			0.12 (0.12, 0.12)	0.06 (0.06, 0.06)			0 (0, 0)	0 (0, 0)			0 (0, 0)	0 (0, 0)
TEfus+	TC1	rate			0.031 (0.017, 0.078)	0.027 (0.018, 0.044)			0.026 (0.018, 0.044)	0.027 (0.017, 0.045)			0.029 (0.017, 0.055)	0.03 (0, 0.089)			0 (0, 0.028)	0.039 (0, 0.392)
TEfus+	TC3	count			49	49			49	49			49	49			49	49
TEfus+	TC3	time			40 (28, 54)	40 (28, 54)			40 (28, 54)	40 (28, 54)			40 (28, 54)	40 (28, 54)			40 (28, 54)	40 (28, 54)
TEfus+	TC3	n			5 (2, 8)	14 (10, 23)			12 (8, 20)	10 (6, 18)			12 (8, 23)	2 (1, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC3	post_p			0.42 (0.29, 0.48)	0.18 (0.03, 0.37)			0.28 (0.05, 0.47)	0.34 (0.12, 0.47)			0.44 (0.31, 0.49)	0.46 (0.39, 0.49)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC3	r_prob			0 (0, 0)	0 (0, 0)			0.06 (0.06, 0.06)	0.06 (0.06, 0.06)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)			0.5 (0.5, 0.5)	0.33 (0.33, 0.33)
TEfus+	TC3	rate			0.035 (0.019, 0.074)	0.028 (0.017, 0.043)			0.028 (0.019, 0.048)	0.026 (0.019, 0.041)			0.016 (0.009, 0.024)	0.02 (0, 0.055)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	count			3	3			3	3			3	3			3	3
TEfus+	TC4	time			39 (23, 46)	39 (23, 46)			39 (23, 46)	39 (23, 46)			39 (23, 46)	39 (23, 46)			39 (23, 46)	39 (23, 46)
TEfus+	TC4	n			4 (2, 7)	19 (15, 25)			8 (4, 10)	12 (10, 18)			7 (6, 9)	3 (3, 5)			0 (0, 0)	0 (0, 0)
TEfus+	TC4	post_p			0.43 (0.2, 0.47)	0.42 (0.21, 0.42)			0.37 (0.14, 0.39)	0.35 (0.35, 0.46)			0.26 (0.15, 0.42)	0.46 (0.44, 0.47)			NA (NA, NA)	NA (NA, NA)
TEfus+	TC4	r_prob			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.31 (0.31, 0.31)			0 (0, 0)	0.33 (0.33, 0.33)			0 (0, 0)	0.33 (0.33, 0.33)
TEfus+	TC4	rate			0.052 (0.027, 0.07)	0.022 (0.02, 0.022)			0.022 (0.019, 0.081)	0.018 (0.011, 0.026)			0.031 (0.022, 0.046)	0.023 (0.016, 0.027)			NA (NA, NA)	NA (NA, NA)
PI3K+	TC1	count		209		209		209		209		209		209		209		209
PI3K+	TC1	time		44 (32, 55)		44 (32, 55)		44 (32, 55)		44 (32, 55)		44 (32, 55)		44 (32, 55)		44 (32, 55)		44 (32, 55)
PI3K+	TC1	n		14 (8, 28)		15 (9, 26)		16 (8, 34)		10 (6, 19)		0 (0, 0)		2 (0, 5)		3 (1, 7)		0 (0, 0)
PI3K+	TC1	post_p		0.35 (0.1, 0.48)		0.17 (0.03, 0.44)		0.34 (0.12, 0.47)		0.24 (0.06, 0.46)		NA (NA, NA)		0.44 (0.34, 0.49)		0.44 (0.26, 0.49)		NA (NA, NA)
PI3K+	TC1	r_prob		0.27 (0.27, 0.27)		0.07 (0.07, 0.07)		0.07 (0.07, 0.07)		0.06 (0.06, 0.06)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC1	rate		0.028 (0.02, 0.048)		0.027 (0.018, 0.043)		0.028 (0.021, 0.043)		0.027 (0.018, 0.052)		0.081 (0.081, 0.081)		0.03 (0, 0.079)		0.032 (0.015, 0.084)		0 (0, 0.398)
PI3K+	TC2	count		8		8		8		8		8		8		8		8
PI3K+	TC2	time		30 (23, 41)		30 (23, 41)		30 (23, 41)		30 (23, 41)		30 (23, 41)		30 (23, 41)		30 (23, 41)		30 (23, 41)
PI3K+	TC2	n		9 (7, 14)		17 (9, 24)		16 (11, 18)		11 (7, 17)		0 (0, 0)		1 (0, 3)		2 (1, 4)		0 (0, 0)
PI3K+	TC2	post_p		0.39 (0.05, 0.5)		0.45 (0.4, 0.48)		0.27 (0.11, 0.47)		0.4 (0.3, 0.48)		NA (NA, NA)		0.47 (0.42, 0.49)		0.44 (0.36, 0.46)		NA (NA, NA)
PI3K+	TC2	r_prob		0.07 (0.07, 0.07)		0.27 (0.27, 0.27)		0.27 (0.27, 0.27)		0.25 (0.25, 0.25)		0 (0, 0)		0 (0, 0)		0 (0, 0)		0 (0, 0)
PI3K+	TC2	rate		0.029 (0.015, 0.064)		0.014 (0.012, 0.02)		0.028 (0.013, 0.038)		0.023 (0.008, 0.031)		NA (NA, NA)		0.029 (0, 0.972)		0.037 (0.029, 0.267)		NA (NA, NA)
PI3K+	TC3	count		85		85		85		85		85		85		85		85
PI3K+	TC3	time		40 (29, 54)		40 (29, 54)		40 (29, 54)		40 (29, 54)		40 (29, 54)		40 (29, 54)		40 (29, 54)		40 (29, 54)
PI3K+	TC3	n		12 (6, 26)		15 (9, 23)		13 (9, 27)		9 (6, 17)		0 (0, 0)		3 (0, 6)		4 (0, 6)		0 (0, 0)
PI3K+	TC3	post_p		0.31 (0.12, 0.47)		0.14 (0.03, 0.42)		0.27 (0.06, 0.43)		0.27 (0.09, 0.45)		NA (NA, NA)		0.48 (0.42, 0.5)		0.47 (0.42, 0.5)		NA (NA, NA)
PI3K+	TC3	r_prob		0 (0, 0)		0 (0, 0)		0 (0, 0)		0.06 (0.06, 0.06)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)		0.33 (0.33, 0.33)
PI3K+	TC3	rate		0.031 (0.022, 0.049)		0.032 (0.019, 0.047)		0.03 (0.021, 0.049)		0.028 (0.02, 0.052)		NA (NA, NA)		0.016 (0, 0.058)		0.016 (0.001, 0.037)		0 (0, 0)