Several treatments more effective in distinctive signatures: (TC2, TEfus+); (TC3, HRD+); (TC4,PI3K )
| signature | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.026, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.025, shape = 1.3 |
| all | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 35.8, median = 29.3 | mean = 32, median = 26.2 | mean = 36.8, median = 30.1 |
| all | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.92, hr = 1.12 | af = 0.82, hr = 1.29 | af = 0.94, hr = 1.08 |
| HRD+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.024, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.028, shape = 1.3 |
| HRD+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 37.9, median = 31 | mean = 78.1, median = 63.8 | mean = 32.9, median = 26.9 |
| HRD+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.97, hr = 1.04 | af = 2, hr = 0.41 | af = 0.84, hr = 1.25 |
| TP53+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.025, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.023, shape = 1.3 |
| TP53+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 37.2, median = 30.4 | mean = 30.2, median = 24.7 | mean = 39.4, median = 32.2 |
| TP53+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.95, hr = 1.07 | af = 0.77, hr = 1.4 | af = 1.01, hr = 0.99 |
| TEfus+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.028, shape = 1.3 | scale = 0.021, shape = 1.3 |
| TEfus+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 72.6, median = 59.3 | mean = 32.8, median = 26.8 | mean = 43.2, median = 35.3 |
| TEfus+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.86, hr = 0.45 | af = 0.84, hr = 1.25 | af = 1.11, hr = 0.88 |
| PI3K+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.023, shape = 1.3 | scale = 0.03, shape = 1.3 | scale = 0.012, shape = 1.3 |
| PI3K+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 40.6, median = 33.2 | mean = 30.7, median = 25.1 | mean = 78.4, median = 64 |
| PI3K+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.04, hr = 0.95 | af = 0.79, hr = 1.36 | af = 2.01, hr = 0.4 |
| subtype | var | Other | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| —- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| —- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| —+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| —+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| —+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| –+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| –+- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| –+- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| –++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| –++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| –++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| -+– | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| -+– | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| -+– | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| -+-+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+-+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 |
| -+-+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 |
| -++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.031, shape = 1.3 |
| -++- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 | mean = 29.4, median = 24 |
| -++- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 | af = 0.75, hr = 1.44 |
| -+++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 |
| -+++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 29.4, median = 24 | mean = 79.9, median = 65.3 |
| -+++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 0.75, hr = 1.44 | af = 2.05, hr = 0.39 |
| +— | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +— | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +— | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| +–+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +–+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| +–+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| +-+- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +-+- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +-+- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| +-++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| +-++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| +-++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| ++– | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| ++– | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| ++– | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| ++-+ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.031, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++-+ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 29.4, median = 24 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| ++-+ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 0.75, hr = 1.44 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
| +++- | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.031, shape = 1.3 |
| +++- | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 29.4, median = 24 |
| +++- | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 0.75, hr = 1.44 |
| ++++ | param | scale = 0.024, shape = 1.3 | scale = 0.029, shape = 1.3 | scale = 0.013, shape = 1.3 | scale = 0.012, shape = 1.3 | scale = 0.012, shape = 1.3 |
| ++++ | summary | mean = 39, median = 31.9 | mean = 31.9, median = 26.1 | mean = 70.5, median = 57.5 | mean = 78.1, median = 63.8 | mean = 78.1, median = 63.8 |
| ++++ | effect | af = 1, hr = 1 | af = 0.82, hr = 1.3 | af = 1.8, hr = 0.46 | af = 2, hr = 0.41 | af = 2, hr = 0.41 |
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| Characteristics | Overall | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| Error signature | 0.172 | 0.02 | 0.052 | 0.024 | 0.086 |
| Error subgroup | 0.264 | 0.02 | 0.106 | 0.024 | 0.144 |
| Power signature | 0.958 | 0.00 | 0.640 | 0.664 | 0.724 |
| Power subgroup | 0.978 | 0.00 | 0.692 | 0.688 | 0.810 |
| signature | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| all | graduation | 0 | 4 | 13 | 11 | 34 |
| all | futility | 0 | 50 | 2 | 2 | 0 |
| all | max_n | 0 | 0 | 0 | 0 | 0 |
| all | n | 651 (605, 699) | 274 (168, 397) | 296 (194, 411) | 267 (188, 386) | 276 (165, 391) |
| all | n_unique | 651 (605, 699) | 274 (168, 397) | 296 (194, 411) | 267 (188, 386) | 276 (165, 391) |
| all | time_trial | 60 (60, 60) | 60 (57, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) |
| all | time_stop | NA (NA, NA) | 46 (19, 56) | 12 (8, 19) | 13 (11, 18) | 12 (10, 17) |
| all | post_p | NA (NA, NA) | 0.04 (0, 0.28) | 0.95 (0.58, 1) | 0.47 (0.11, 0.89) | 0.99 (0.83, 1) |
| all | rate | 0.023 (0.021, 0.024) | 0.028 (0.025, 0.031) | 0.02 (0.017, 0.023) | 0.024 (0.021, 0.026) | 0.019 (0.016, 0.021) |
| HRD+ | graduation | 0 | 1 | 9 | 332 | 0 |
| HRD+ | futility | 0 | 13 | 4 | 0 | 1 |
| HRD+ | max_n | 0 | 0 | 0 | 0 | 0 |
| HRD+ | n | 87 (73, 103) | 34 (22, 52) | 38 (22, 57) | 54 (50, 78) | 34 (18, 52) |
| HRD+ | n_unique | 87 (73, 103) | 34 (22, 52) | 38 (22, 57) | 54 (50, 78) | 34 (18, 52) |
| HRD+ | time_trial | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 49 (38, 60) | 60 (60, 60) |
| HRD+ | time_stop | NA (NA, NA) | 57 (51, 60) | 53 (48, 58) | 44 (37, 54) | 60 (60, 60) |
| HRD+ | post_p | NA (NA, NA) | 0.19 (0.02, 0.58) | 0.67 (0.25, 0.95) | 1 (0.98, 1) | 0.4 (0.08, 0.81) |
| HRD+ | rate | 0.022 (0.018, 0.026) | 0.028 (0.021, 0.038) | 0.019 (0.014, 0.026) | 0.009 (0.006, 0.012) | 0.024 (0.017, 0.032) |
| TP53+ | graduation | 0 | 5 | 22 | 1 | 30 |
| TP53+ | futility | 0 | 211 | 11 | 134 | 5 |
| TP53+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TP53+ | n | 241 (216, 263) | 93 (52, 152) | 122 (71, 177) | 89 (51, 150) | 108 (53, 167) |
| TP53+ | n_unique | 241 (216, 263) | 93 (52, 152) | 122 (71, 177) | 89 (51, 150) | 108 (53, 167) |
| TP53+ | time_trial | 60 (60, 60) | 60 (34, 60) | 60 (60, 60) | 60 (36, 60) | 60 (60, 60) |
| TP53+ | time_stop | NA (NA, NA) | 42 (29, 54) | 31 (24, 51) | 38 (28, 53) | 29 (21, 43) |
| TP53+ | post_p | NA (NA, NA) | 0.13 (0.01, 0.48) | 0.9 (0.46, 1) | 0.11 (0.01, 0.48) | 0.96 (0.66, 1) |
| TP53+ | rate | 0.022 (0.02, 0.025) | 0.028 (0.024, 0.033) | 0.019 (0.015, 0.023) | 0.028 (0.024, 0.034) | 0.017 (0.013, 0.021) |
| TEfus+ | graduation | 0 | 0 | 320 | 0 | 10 |
| TEfus+ | futility | 0 | 265 | 0 | 49 | 3 |
| TEfus+ | max_n | 0 | 0 | 0 | 0 | 0 |
| TEfus+ | n | 208 (182, 233) | 61 (48, 105) | 120 (56, 187) | 78 (52, 128) | 90 (53, 142) |
| TEfus+ | n_unique | 208 (182, 233) | 61 (48, 105) | 120 (56, 187) | 78 (52, 128) | 90 (53, 142) |
| TEfus+ | time_trial | 60 (60, 60) | 58 (36, 60) | 49 (27, 60) | 60 (60, 60) | 60 (60, 60) |
| TEfus+ | time_stop | NA (NA, NA) | 46 (33, 57) | 39 (26, 56) | 40 (28, 54) | 28 (22, 41) |
| TEfus+ | post_p | NA (NA, NA) | 0.01 (0, 0.14) | 1 (0.98, 1) | 0.14 (0.01, 0.59) | 0.85 (0.42, 0.99) |
| TEfus+ | rate | 0.018 (0.016, 0.02) | 0.028 (0.023, 0.034) | 0.01 (0.008, 0.012) | 0.022 (0.018, 0.027) | 0.015 (0.012, 0.018) |
| PI3K+ | graduation | 0 | 0 | 10 | 0 | 362 |
| PI3K+ | futility | 0 | 209 | 8 | 85 | 0 |
| PI3K+ | max_n | 0 | 0 | 0 | 0 | 0 |
| PI3K+ | n | 224 (198, 249) | 76 (50, 129) | 110 (60, 164) | 81 (50, 138) | 108 (54, 195) |
| PI3K+ | n_unique | 224 (198, 249) | 76 (50, 129) | 110 (60, 164) | 81 (50, 138) | 108 (54, 195) |
| PI3K+ | time_trial | 60 (60, 60) | 60 (37, 60) | 60 (60, 60) | 60 (43, 60) | 42 (26, 60) |
| PI3K+ | time_stop | NA (NA, NA) | 44 (32, 55) | 32 (23, 53) | 40 (29, 54) | 36 (25, 52) |
| PI3K+ | post_p | NA (NA, NA) | 0.08 (0, 0.39) | 0.92 (0.59, 1) | 0.12 (0.01, 0.49) | 1 (1, 1) |
| PI3K+ | rate | 0.022 (0.019, 0.024) | 0.028 (0.023, 0.034) | 0.017 (0.014, 0.021) | 0.027 (0.022, 0.032) | 0.009 (0.007, 0.011) |
| subtype | var | Control | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|---|
| —- | graduation | 0 | 4 | 13 | 11 | 34 |
| —- | futility | 0 | 50 | 2 | 2 | 0 |
| —- | max_n | 0 | 0 | 0 | 0 | 0 |
| —- | n | 205 (173, 232) | 96 (28, 206) | 58 (23, 165) | 66 (21, 173) | 59 (18, 158) |
| —- | n_unique | 205 (173, 232) | 96 (28, 206) | 58 (23, 165) | 66 (21, 173) | 59 (18, 158) |
| —- | post_p | NA (NA, NA) | 0.35 (0.05, 0.81) | 0.19 (0.03, 0.62) | 0.18 (0.03, 0.66) | 0.19 (0.02, 0.61) |
| —- | rate | 0.025 (0.022, 0.029) | 0.028 (0.023, 0.037) | 0.031 (0.025, 0.041) | 0.031 (0.025, 0.041) | 0.031 (0.025, 0.043) |
| —+ | graduation | 0 | 4 | 23 | 11 | 395 |
| —+ | futility | 0 | 226 | 10 | 87 | 0 |
| —+ | max_n | 0 | 0 | 0 | 0 | 0 |
| —+ | n | 47 (36, 57) | 17 (8, 39) | 16 (7, 38) | 15 (7, 36) | 24 (9, 46) |
| —+ | n_unique | 47 (36, 57) | 17 (8, 39) | 16 (7, 38) | 15 (7, 36) | 24 (9, 46) |
| —+ | post_p | NA (NA, NA) | 0.36 (0.08, 0.74) | 0.3 (0.07, 0.68) | 0.3 (0.09, 0.7) | 0.99 (0.9, 1) |
| —+ | rate | 0.026 (0.02, 0.032) | 0.029 (0.02, 0.047) | 0.03 (0.021, 0.054) | 0.031 (0.021, 0.047) | 0.009 (0.005, 0.015) |
| –+- | graduation | 0 | 4 | 333 | 11 | 44 |
| –+- | futility | 0 | 287 | 2 | 51 | 3 |
| –+- | max_n | 0 | 0 | 0 | 0 | 0 |
| –+- | n | 13 (8, 18) | 6 (3, 11) | 7 (3, 15) | 6 (3, 13) | 6 (2, 11) |
| –+- | n_unique | 13 (8, 18) | 6 (3, 11) | 7 (3, 15) | 6 (3, 13) | 6 (2, 11) |
| –+- | post_p | NA (NA, NA) | 0.36 (0.12, 0.66) | 0.78 (0.5, 0.94) | 0.34 (0.1, 0.65) | 0.34 (0.12, 0.59) |
| –+- | rate | 0.018 (0.009, 0.03) | 0.029 (0.014, 0.064) | 0.009 (0, 0.02) | 0.03 (0.013, 0.063) | 0.032 (0.016, 0.07) |
| –++ | graduation | 0 | 4 | 336 | 11 | 398 |
| –++ | futility | 0 | 359 | 10 | 125 | 3 |
| –++ | max_n | 0 | 0 | 0 | 0 | 0 |
| –++ | n | 69 (53, 83) | 16 (9, 40) | 36 (17, 68) | 17 (8, 46) | 29 (14, 65) |
| –++ | n_unique | 69 (53, 83) | 16 (9, 40) | 36 (17, 68) | 17 (8, 46) | 29 (14, 65) |
| –++ | post_p | NA (NA, NA) | 0.11 (0.01, 0.4) | 0.95 (0.66, 1) | 0.08 (0.01, 0.3) | 0.97 (0.74, 1) |
| –++ | rate | 0.018 (0.014, 0.023) | 0.03 (0.02, 0.046) | 0.01 (0.007, 0.015) | 0.031 (0.022, 0.049) | 0.009 (0.006, 0.014) |
| -+– | graduation | 0 | 9 | 35 | 12 | 64 |
| -+– | futility | 0 | 219 | 13 | 136 | 5 |
| -+– | max_n | 0 | 0 | 0 | 0 | 0 |
| -+– | n | 84 (68, 102) | 34 (13, 75) | 31 (15, 73) | 29 (11, 69) | 30 (10, 70) |
| -+– | n_unique | 84 (68, 102) | 34 (13, 75) | 31 (15, 73) | 29 (11, 69) | 30 (10, 70) |
| -+– | post_p | NA (NA, NA) | 0.38 (0.1, 0.81) | 0.3 (0.05, 0.73) | 0.3 (0.06, 0.75) | 0.31 (0.05, 0.77) |
| -+– | rate | 0.025 (0.021, 0.031) | 0.029 (0.022, 0.041) | 0.031 (0.024, 0.044) | 0.031 (0.023, 0.044) | 0.03 (0.022, 0.048) |
| -+-+ | graduation | 0 | 7 | 44 | 11 | 403 |
| -+-+ | futility | 0 | 303 | 19 | 161 | 3 |
| -+-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+-+ | n | 57 (45, 69) | 18 (8, 46) | 20 (9, 43) | 17 (7, 45) | 28 (12, 55) |
| -+-+ | n_unique | 57 (45, 69) | 18 (8, 46) | 20 (9, 43) | 17 (7, 45) | 28 (12, 55) |
| -+-+ | post_p | NA (NA, NA) | 0.39 (0.09, 0.8) | 0.3 (0.06, 0.7) | 0.28 (0.06, 0.7) | 1 (0.93, 1) |
| -+-+ | rate | 0.025 (0.02, 0.032) | 0.028 (0.019, 0.044) | 0.031 (0.022, 0.047) | 0.032 (0.021, 0.047) | 0.009 (0.006, 0.014) |
| -++- | graduation | 0 | 7 | 337 | 11 | 71 |
| -++- | futility | 0 | 375 | 10 | 173 | 8 |
| -++- | max_n | 0 | 0 | 0 | 0 | 0 |
| -++- | n | 52 (41, 63) | 13 (6, 31) | 33 (15, 57) | 14 (7, 37) | 14 (6, 40) |
| -++- | n_unique | 52 (41, 63) | 13 (6, 31) | 33 (15, 57) | 14 (7, 37) | 14 (6, 40) |
| -++- | post_p | NA (NA, NA) | 0.18 (0.03, 0.53) | 0.98 (0.83, 1) | 0.13 (0.02, 0.46) | 0.15 (0.02, 0.42) |
| -++- | rate | 0.018 (0.013, 0.023) | 0.029 (0.02, 0.045) | 0.009 (0.005, 0.013) | 0.031 (0.021, 0.051) | 0.031 (0.021, 0.053) |
| -+++ | graduation | 0 | 7 | 340 | 11 | 404 |
| -+++ | futility | 0 | 404 | 16 | 195 | 6 |
| -+++ | max_n | 0 | 0 | 0 | 0 | 0 |
| -+++ | n | 38 (26, 48) | 11 (6, 24) | 20 (8, 39) | 12 (6, 29) | 17 (7, 34) |
| -+++ | n_unique | 38 (26, 48) | 11 (6, 24) | 20 (8, 39) | 12 (6, 29) | 17 (7, 34) |
| -+++ | post_p | NA (NA, NA) | 0.18 (0.04, 0.5) | 0.86 (0.5, 0.98) | 0.14 (0.02, 0.41) | 0.91 (0.65, 0.99) |
| -+++ | rate | 0.018 (0.013, 0.025) | 0.029 (0.019, 0.048) | 0.01 (0.006, 0.018) | 0.031 (0.02, 0.048) | 0.009 (0.004, 0.015) |
| +— | graduation | 0 | 5 | 22 | 343 | 34 |
| +— | futility | 0 | 63 | 6 | 2 | 1 |
| +— | max_n | 0 | 0 | 0 | 0 | 0 |
| +— | n | 42 (33, 53) | 15 (7, 30) | 14 (6, 27) | 30 (21, 45) | 13 (5, 28) |
| +— | n_unique | 42 (33, 53) | 15 (7, 30) | 14 (6, 27) | 30 (21, 45) | 13 (5, 28) |
| +— | post_p | NA (NA, NA) | 0.38 (0.08, 0.78) | 0.32 (0.07, 0.71) | 1 (0.94, 1) | 0.31 (0.08, 0.7) |
| +— | rate | 0.026 (0.019, 0.033) | 0.028 (0.018, 0.051) | 0.031 (0.02, 0.05) | 0.009 (0.005, 0.013) | 0.032 (0.02, 0.053) |
| +–+ | graduation | 0 | 5 | 32 | 325 | 395 |
| +–+ | futility | 0 | 231 | 13 | 58 | 1 |
| +–+ | max_n | 0 | 0 | 0 | 0 | 0 |
| +–+ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +–+ | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| +–+ | rate | 0.039 (0, 0.084) | 0.081 (0.081, 0.081) | 0.063 (0, 1.075) | 0.091 (0.066, 0.116) | 0 (0, 0) |
| +-+- | graduation | 0 | 4 | 337 | 342 | 44 |
| +-+- | futility | 0 | 293 | 6 | 41 | 4 |
| +-+- | max_n | 0 | 0 | 0 | 0 | 0 |
| +-+- | n | 30 (22, 38) | 9 (5, 18) | 13 (5, 25) | 18 (10, 28) | 10 (4, 22) |
| +-+- | n_unique | 30 (22, 38) | 9 (5, 18) | 13 (5, 25) | 18 (10, 28) | 10 (4, 22) |
| +-+- | post_p | NA (NA, NA) | 0.21 (0.04, 0.54) | 0.8 (0.47, 0.96) | 0.88 (0.57, 0.98) | 0.18 (0.04, 0.47) |
| +-+- | rate | 0.018 (0.012, 0.025) | 0.03 (0.017, 0.054) | 0.01 (0.004, 0.019) | 0.009 (0.005, 0.016) | 0.032 (0.019, 0.055) |
| +-++ | graduation | 0 | 4 | 340 | 324 | 398 |
| +-++ | futility | 0 | 361 | 13 | 87 | 4 |
| +-++ | max_n | 0 | 0 | 0 | 0 | 0 |
| +-++ | n | 6 (2, 10) | 3 (1, 6) | 3 (0, 6) | 3 (1, 7) | 3 (0, 6) |
| +-++ | n_unique | 6 (2, 10) | 3 (1, 6) | 3 (0, 6) | 3 (1, 7) | 3 (0, 6) |
| +-++ | post_p | NA (NA, NA) | 0.42 (0.27, 0.56) | 0.53 (0.42, 0.67) | 0.54 (0.41, 0.71) | 0.53 (0.42, 0.67) |
| +-++ | rate | 0.016 (0, 0.039) | 0.028 (0.007, 0.076) | 0.009 (0, 0.034) | 0.009 (0, 0.031) | 0.009 (0, 0.027) |
| ++– | graduation | 0 | 10 | 44 | 324 | 64 |
| ++– | futility | 0 | 224 | 17 | 75 | 6 |
| ++– | max_n | 0 | 0 | 0 | 0 | 0 |
| ++– | n | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++– | n_unique | 1 (0, 3) | 0 (0, 2) | 1 (0, 2) | 0 (0, 2) | 0 (0, 2) |
| ++– | post_p | NA (NA, NA) | 0.49 (0.42, 0.57) | 0.5 (0.43, 0.57) | 0.54 (0.46, 0.59) | 0.48 (0.41, 0.57) |
| ++– | rate | 0.026 (0, 0.089) | 0.028 (0, 0.13) | 0.025 (0, 0.108) | 0 (0, 0.052) | 0.034 (0, 0.155) |
| ++-+ | graduation | 0 | 8 | 53 | 312 | 403 |
| ++-+ | futility | 0 | 306 | 22 | 96 | 4 |
| ++-+ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++-+ | n | 8 (4, 13) | 4 (1, 8) | 5 (2, 9) | 5 (1, 9) | 3 (1, 7) |
| ++-+ | n_unique | 8 (4, 13) | 4 (1, 8) | 5 (2, 9) | 5 (1, 9) | 3 (1, 7) |
| ++-+ | post_p | NA (NA, NA) | 0.42 (0.22, 0.6) | 0.43 (0.22, 0.63) | 0.65 (0.45, 0.86) | 0.62 (0.42, 0.83) |
| ++-+ | rate | 0.025 (0.01, 0.045) | 0.03 (0.011, 0.073) | 0.029 (0.011, 0.063) | 0.009 (0, 0.025) | 0.009 (0, 0.03) |
| +++- | graduation | 0 | 7 | 341 | 322 | 71 |
| +++- | futility | 0 | 378 | 14 | 104 | 9 |
| +++- | max_n | 0 | 0 | 0 | 0 | 0 |
| +++- | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| +++- | post_p | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) |
| +++- | rate | 0.105 (0, 0.35) | 0 (0, 0.04) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.07) |
| ++++ | graduation | 0 | 7 | 344 | 311 | 404 |
| ++++ | futility | 0 | 405 | 19 | 122 | 7 |
| ++++ | max_n | 0 | 0 | 0 | 0 | 0 |
| ++++ | n | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | n_unique | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| ++++ | post_p | NA (NA, NA) | 0.54 (0.54, 0.54) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.49 (0.48, 0.52) |
| ++++ | rate | 0 (0, 0.251) | 0 (0, 0.112) | 0 (0, 0.023) | 0 (0, 0.021) | 0 (0, 0.023) |
Posterior probabilities
Randomization probabilities
PFS rates
Posterior probabilities
Randomization probabilities
PFS rates
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 4 | 13 | 11 | 34 |
| all | time_stop | 12 (10, 15) | 14 (10, 19) | 12 (11, 17) | 12 (10, 17) |
| all | n_trt | 77 (67, 101) | 93 (68, 137) | 65 (51, 79) | 62 (52, 90) |
| all | n_control | 104 (95, 130) | 119 (84, 159) | 102 (94, 135) | 96 (79, 138) |
| all | post_p | 0.95 (0.89, 0.98) | 0.92 (0.87, 0.98) | 0.94 (0.88, 0.99) | 0.92 (0.88, 0.97) |
| all | order | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) | 1 (1, 1) |
| HRD+ | count | 1 | 9 | 332 | |
| HRD+ | time_stop | 47 (47, 47) | 53 (50, 58) | 44 (37, 54) | |
| HRD+ | n_trt | 53 (53, 53) | 51 (50, 53) | 52 (50, 65) | |
| HRD+ | n_control | 79 (79, 79) | 74 (55, 84) | 60 (44, 77) | |
| HRD+ | post_p | 0.93 (0.93, 0.93) | 0.98 (0.95, 1) | 1 (0.96, 1) | |
| HRD+ | order | 2 (2, 2) | 2 (1.8, 3.4) | 2 (1, 3) | |
| TP53+ | count | 5 | 22 | 1 | 30 |
| TP53+ | time_stop | 26 (23, 29) | 31 (24, 48) | 19 (19, 19) | 30 (21, 44) |
| TP53+ | n_trt | 54 (51, 57) | 90 (63, 143) | 51 (51, 51) | 63 (51, 118) |
| TP53+ | n_control | 75 (71, 87) | 106 (71, 170) | 62 (62, 62) | 98 (58, 165) |
| TP53+ | post_p | 0.91 (0.9, 0.94) | 0.99 (0.9, 1) | 0.98 (0.98, 0.98) | 0.98 (0.95, 1) |
| TP53+ | order | 1 (1, 1.6) | 2 (1, 3) | 1 (1, 1) | 2 (1, 3.1) |
| TEfus+ | count | 320 | 10 | ||
| TEfus+ | time_stop | 39 (26, 56) | 27 (22, 36) | ||
| TEfus+ | n_trt | 96 (56, 164) | 54 (51, 65) | ||
| TEfus+ | n_control | 116 (70, 190) | 71 (60, 93) | ||
| TEfus+ | post_p | 1 (0.95, 1) | 0.96 (0.93, 0.98) | ||
| TEfus+ | order | 2 (1, 3) | 1 (1, 2) | ||
| PI3K+ | count | 10 | 362 | ||
| PI3K+ | time_stop | 37 (28, 54) | 36 (25, 52) | ||
| PI3K+ | n_trt | 74 (60, 113) | 98 (60, 161) | ||
| PI3K+ | n_control | 114 (83, 205) | 112 (67, 183) | ||
| PI3K+ | post_p | 1 (0.93, 1) | 1 (0.99, 1) | ||
| PI3K+ | order | 2 (1, 3.1) | 1 (1, 3) |
| signature | var | TC1 | TC2 | TC3 | TC4 |
|---|---|---|---|---|---|
| all | count | 50 | 2 | 2 | |
| all | time_stop | 46 (27, 56) | 8 (8, 8) | 18 (17, 18) | |
| all | n_trt | 175 (120, 290) | 57 (57, 57) | 82 (74, 91) | |
| all | n_control | 470 (242, 610) | 63 (60, 66) | 143 (143, 143) | |
| all | post_p | 0 (0, 0.02) | 0.24 (0.2, 0.29) | 0.05 (0.03, 0.08) | |
| all | order | 2.5 (1, 5) | 1 (1, 1) | 1 (1, 1) | |
| HRD+ | count | 13 | 4 | 1 | |
| HRD+ | time_stop | 58 (51, 60) | 52 (49, 56) | 60 (60, 60) | |
| HRD+ | n_trt | 53 (51, 61) | 58 (54, 63) | 51 (51, 51) | |
| HRD+ | n_control | 84 (78, 103) | 74 (72, 88) | 89 (89, 89) | |
| HRD+ | post_p | 0.1 (0.01, 0.17) | 0.28 (0.16, 0.3) | 0.04 (0.04, 0.04) | |
| HRD+ | order | 3 (1, 4) | 3 (2.3, 4.4) | 1 (1, 1) | |
| TP53+ | count | 211 | 11 | 134 | 5 |
| TP53+ | time_stop | 42 (30, 54) | 31 (26, 52) | 38 (28, 53) | 26 (21, 29) |
| TP53+ | n_trt | 69 (51, 116) | 65 (57, 84) | 63 (50, 100) | 52 (50, 63) |
| TP53+ | n_control | 157 (93, 214) | 114 (67, 200) | 135 (90, 197) | 90 (56, 108) |
| TP53+ | post_p | 0.08 (0.01, 0.21) | 0.18 (0.05, 0.26) | 0.09 (0.01, 0.21) | 0.15 (0.04, 0.3) |
| TP53+ | order | 2 (1, 3) | 1 (1, 4) | 1 (1, 3) | 1 (1, 1) |
| TEfus+ | count | 265 | 49 | 3 | |
| TEfus+ | time_stop | 46 (33, 57) | 40 (28, 54) | 39 (23, 46) | |
| TEfus+ | n_trt | 58 (50, 94) | 58 (50, 80) | 54 (52, 60) | |
| TEfus+ | n_control | 141 (90, 202) | 113 (68, 187) | 132 (62, 166) | |
| TEfus+ | post_p | 0.02 (0, 0.14) | 0.04 (0, 0.21) | 0.06 (0.03, 0.16) | |
| TEfus+ | order | 2 (1, 3) | 2 (1, 4) | 1 (1, 1.8) | |
| PI3K+ | count | 209 | 8 | 85 | |
| PI3K+ | time_stop | 44 (32, 55) | 30 (23, 41) | 40 (29, 54) | |
| PI3K+ | n_trt | 63 (51, 96) | 54 (51, 63) | 56 (50, 87) | |
| PI3K+ | n_control | 150 (91, 210) | 84 (61, 134) | 145 (81, 200) | |
| PI3K+ | post_p | 0.05 (0.01, 0.19) | 0.09 (0.04, 0.29) | 0.06 (0.01, 0.19) | |
| PI3K+ | order | 2 (1, 4) | 2 (1, 3) | 2 (1, 4) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 |
| all | TC1 | time | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) | 12 (10, 15) |
| all | TC1 | n | 32 (26, 42) | 8 (7, 10) | 2 (0, 5) | 8 (6, 11) | 8 (7, 13) | 4 (3, 5) | 4 (2, 4) | 4 (3, 5) | 5 (3, 7) | 0 (0, 0) | 2 (0, 4) | 1 (0, 1) | 0 (0, 0) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.73 (0.61, 0.92) | 0.52 (0.51, 0.57) | 0.52 (0.52, 0.52) | 0.52 (0.51, 0.56) | 0.53 (0.51, 0.55) | 0.52 (0.51, 0.53) | 0.54 (0.51, 0.55) | 0.52 (0.51, 0.54) | 0.53 (0.51, 0.55) | NA (NA, NA) | 0.51 (0.5, 0.51) | 0.52 (0.52, 0.52) | NA (NA, NA) | 0.52 (0.51, 0.54) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.007 (0.001, 0.015) | 0.014 (0.003, 0.021) | 0 (0, 0) | 0 (0, 0) | 0.007 (0, 0.016) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.014) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 |
| all | TC2 | time | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) | 14 (10, 19) |
| all | TC2 | n | 27 (21, 46) | 3 (1, 10) | 1 (0, 5) | 12 (4, 16) | 17 (11, 19) | 8 (5, 12) | 8 (5, 13) | 6 (3, 12) | 3 (1, 6) | 0 (0, 0) | 2 (1, 6) | 0 (0, 1) | 0 (0, 0) | 0 (0, 2) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.64 (0.56, 0.76) | 0.52 (0.51, 0.54) | 0.53 (0.51, 0.56) | 0.56 (0.51, 0.67) | 0.56 (0.52, 0.68) | 0.54 (0.52, 0.61) | 0.55 (0.52, 0.58) | 0.54 (0.5, 0.66) | 0.52 (0.5, 0.56) | NA (NA, NA) | 0.52 (0.51, 0.54) | 0.52 (0.51, 0.52) | NA (NA, NA) | 0.53 (0.51, 0.55) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.013 (0.007, 0.018) | 0 (0, 0.015) | 0 (0, 0.002) | 0 (0, 0.005) | 0.011 (0, 0.026) | 0 (0, 0.018) | 0 (0, 0.018) | 0 (0, 0) | 0 (0, 0.031) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 |
| all | TC3 | time | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) | 12 (11, 17) |
| all | TC3 | n | 16 (12, 20) | 4 (0, 6) | 1 (0, 2) | 6 (3, 8) | 7 (5, 15) | 4 (2, 6) | 4 (2, 6) | 3 (2, 5) | 11 (7, 13) | 0 (0, 0) | 4 (2, 6) | 1 (0, 2) | 0 (0, 1) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.62 (0.52, 0.78) | 0.53 (0.52, 0.56) | 0.52 (0.5, 0.56) | 0.54 (0.51, 0.55) | 0.55 (0.5, 0.63) | 0.54 (0.51, 0.56) | 0.52 (0.5, 0.55) | 0.52 (0.5, 0.54) | 0.58 (0.52, 0.68) | NA (NA, NA) | 0.54 (0.52, 0.56) | 0.51 (0.51, 0.53) | NA (NA, NA) | 0.53 (0.52, 0.53) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0 (0, 0.024) | 0 (0, 0.007) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.033) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | count | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 | 34 |
| all | TC4 | time | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) | 12 (10, 17) |
| all | TC4 | n | 16 (10, 24) | 6 (4, 11) | 1 (0, 4) | 10 (4, 15) | 7 (4, 14) | 9 (4, 14) | 3 (1, 6) | 4 (2, 11) | 3 (0, 6) | 0 (0, 0) | 3 (0, 6) | 0 (0, 2) | 0 (0, 0) | 1 (0, 3) | 0 (0, 0) | 0 (0, 0) |
| all | TC4 | post_p | 0.62 (0.53, 0.74) | 0.54 (0.51, 0.61) | 0.52 (0.51, 0.55) | 0.55 (0.52, 0.63) | 0.57 (0.52, 0.65) | 0.56 (0.51, 0.6) | 0.52 (0.5, 0.55) | 0.52 (0.5, 0.57) | 0.53 (0.51, 0.57) | NA (NA, NA) | 0.52 (0.5, 0.56) | 0.53 (0.52, 0.56) | NA (NA, NA) | 0.53 (0.5, 0.56) | NA (NA, NA) | NA (NA, NA) |
| all | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) |
| all | TC4 | rate | 0.008 (0, 0.021) | 0 (0, 0.008) | 0 (0, 0) | 0 (0, 0.015) | 0 (0, 0.022) | 0 (0, 0.013) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0.008) | NA (NA, NA) | 0 (0, 0) |
| HRD+ | TC1 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| HRD+ | TC1 | time | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | 47 (47, 47) | ||||||||
| HRD+ | TC1 | n | 36 (36, 36) | 0 (0, 0) | 15 (15, 15) | 0 (0, 0) | 0 (0, 0) | 2 (2, 2) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | post_p | 0.93 (0.93, 0.93) | NA (NA, NA) | 0.71 (0.71, 0.71) | NA (NA, NA) | NA (NA, NA) | 0.55 (0.55, 0.55) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | rate | 0.014 (0.014, 0.014) | NA (NA, NA) | 0.008 (0.008, 0.008) | NA (NA, NA) | NA (NA, NA) | 0.026 (0.026, 0.026) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | count | 9 | 9 | 9 | 9 | 9 | 9 | 9 | 9 | ||||||||
| HRD+ | TC2 | time | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | 53 (50, 58) | ||||||||
| HRD+ | TC2 | n | 21 (13, 26) | 0 (0, 0) | 22 (12, 24) | 5 (3, 6) | 1 (0, 3) | 6 (4, 9) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | post_p | 0.88 (0.71, 0.98) | NA (NA, NA) | 0.82 (0.76, 0.98) | 0.56 (0.51, 0.64) | 0.53 (0.53, 0.53) | 0.56 (0.52, 0.74) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | rate | 0.016 (0.012, 0.02) | NA (NA, NA) | 0.007 (0.002, 0.01) | 0.008 (0, 0.016) | 0.018 (0, 0.034) | 0.016 (0.008, 0.023) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | count | 332 | 332 | 332 | 332 | 332 | 332 | 332 | 332 | ||||||||
| HRD+ | TC3 | time | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | 44 (37, 54) | ||||||||
| HRD+ | TC3 | n | 28 (21, 37) | 0 (0, 0) | 18 (10, 24) | 3 (1, 7) | 0 (0, 2) | 4 (1, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC3 | post_p | 0.97 (0.81, 1) | NA (NA, NA) | 0.8 (0.7, 0.95) | 0.55 (0.51, 0.64) | 0.54 (0.51, 0.57) | 0.57 (0.51, 0.73) | 0.52 (0.52, 0.52) | NA (NA, NA) | ||||||||
| HRD+ | TC3 | r_prob | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC3 | rate | 0.008 (0.003, 0.014) | 0.061 (0.012, 0.11) | 0.007 (0.003, 0.013) | 0 (0, 0.016) | 0 (0, 0.031) | 0.005 (0, 0.02) | 0 (0, 0) | 0 (0, 0.018) | ||||||||
| TP53+ | TC1 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||
| TP53+ | TC1 | time | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | 26 (23, 29) | ||||||||
| TP53+ | TC1 | n | 22 (15, 25) | 9 (4, 17) | 10 (8, 18) | 8 (6, 11) | 0 (0, 1) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.75 (0.71, 0.78) | 0.54 (0.53, 0.85) | 0.62 (0.52, 0.73) | 0.57 (0.54, 0.66) | NA (NA, NA) | 0.52 (0.51, 0.53) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.015 (0.009, 0.02) | 0.006 (0.002, 0.013) | 0.009 (0.008, 0.024) | 0 (0, 0.012) | 0 (0, 0) | 0.012 (0, 0.035) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | count | 22 | 22 | 22 | 22 | 22 | 22 | 22 | 22 | ||||||||
| TP53+ | TC2 | time | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | 31 (24, 48) | ||||||||
| TP53+ | TC2 | n | 32 (18, 42) | 18 (10, 34) | 22 (15, 37) | 15 (7, 28) | 0 (0, 1) | 3 (0, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.78 (0.71, 0.9) | 0.73 (0.54, 0.82) | 0.87 (0.74, 0.96) | 0.75 (0.57, 0.94) | 0.53 (0.53, 0.53) | 0.53 (0.5, 0.56) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.018 (0.011, 0.024) | 0.016 (0.004, 0.022) | 0.006 (0.004, 0.011) | 0.005 (0, 0.009) | 0.039 (0.012, 0.046) | 0.008 (0, 0.038) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| TP53+ | TC3 | time | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | 19 (19, 19) | ||||||||
| TP53+ | TC3 | n | 16 (16, 16) | 13 (13, 13) | 8 (8, 8) | 9 (9, 9) | 2 (2, 2) | 3 (3, 3) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.72 (0.72, 0.72) | 0.73 (0.73, 0.73) | 0.58 (0.58, 0.58) | 0.56 (0.56, 0.56) | NA (NA, NA) | 0.53 (0.53, 0.53) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0 (0, 0) | 0 (0, 0) | 0.015 (0.015, 0.015) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | count | 30 | 30 | 30 | 30 | 30 | 30 | 30 | 30 | ||||||||
| TP53+ | TC4 | time | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | 30 (21, 44) | ||||||||
| TP53+ | TC4 | n | 20 (14, 36) | 20 (15, 39) | 8 (6, 21) | 10 (7, 27) | 0 (0, 1) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.75 (0.71, 0.86) | 0.87 (0.75, 1) | 0.56 (0.52, 0.75) | 0.71 (0.54, 0.92) | 0.54 (0.54, 0.54) | 0.53 (0.51, 0.58) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.016 (0.009, 0.023) | 0.005 (0, 0.01) | 0.013 (0, 0.022) | 0.007 (0, 0.016) | 0 (0, 0.046) | 0 (0, 0.011) | NA (NA, NA) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | count | 320 | 320 | 320 | 320 | 320 | 320 | 320 | 320 | ||||||||
| TEfus+ | TC2 | time | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | 39 (26, 56) | ||||||||
| TEfus+ | TC2 | n | 6 (3, 12) | 31 (17, 56) | 26 (15, 46) | 18 (8, 31) | 10 (5, 22) | 3 (0, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | post_p | 0.61 (0.52, 0.86) | 0.84 (0.71, 0.98) | 0.87 (0.72, 0.99) | 0.75 (0.56, 0.94) | 0.69 (0.52, 0.9) | 0.53 (0.51, 0.6) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC2 | rate | 0.006 (0, 0.018) | 0.008 (0.003, 0.013) | 0.007 (0.002, 0.013) | 0.008 (0, 0.014) | 0.007 (0, 0.016) | 0 (0, 0.019) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||
| TEfus+ | TC4 | time | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | 27 (22, 36) | ||||||||
| TEfus+ | TC4 | n | 2 (1, 5) | 22 (17, 33) | 8 (7, 10) | 13 (6, 19) | 6 (3, 7) | 2 (1, 7) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.53 (0.51, 0.55) | 0.76 (0.74, 0.93) | 0.57 (0.51, 0.65) | 0.67 (0.54, 0.89) | 0.52 (0.5, 0.56) | 0.53 (0.51, 0.59) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0 (0, 0.002) | 0.005 (0, 0.009) | 0.015 (0, 0.024) | 0.004 (0, 0.009) | 0.014 (0, 0.021) | 0 (0, 0.001) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | count | 10 | 10 | 10 | 10 | 10 | 10 | 10 | 10 | ||||||||
| PI3K+ | TC2 | time | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | 37 (28, 54) | ||||||||
| PI3K+ | TC2 | n | 10 (8, 19) | 26 (19, 41) | 18 (9, 29) | 14 (7, 19) | 0 (0, 0) | 2 (1, 6) | 4 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.69 (0.57, 0.87) | 0.85 (0.71, 0.94) | 0.73 (0.51, 0.82) | 0.82 (0.71, 0.92) | NA (NA, NA) | 0.55 (0.51, 0.67) | 0.55 (0.51, 0.62) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.012 (0, 0.018) | 0.008 (0.004, 0.01) | 0.021 (0.013, 0.027) | 0.009 (0, 0.011) | NA (NA, NA) | 0 (0, 0.008) | 0 (0, 0.031) | NA (NA, NA) | ||||||||
| PI3K+ | TC4 | count | 362 | 362 | 362 | 362 | 362 | 362 | 362 | 362 | ||||||||
| PI3K+ | TC4 | time | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | 36 (25, 52) | ||||||||
| PI3K+ | TC4 | n | 21 (10, 37) | 26 (16, 48) | 26 (15, 45) | 16 (8, 29) | 0 (0, 0) | 2 (0, 6) | 3 (1, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC4 | post_p | 0.88 (0.7, 1) | 0.84 (0.72, 0.98) | 0.93 (0.72, 1) | 0.75 (0.55, 0.95) | NA (NA, NA) | 0.53 (0.51, 0.6) | 0.55 (0.51, 0.66) | 0.51 (0.51, 0.51) | ||||||||
| PI3K+ | TC4 | r_prob | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.31 (0.31, 0.31) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC4 | rate | 0.008 (0, 0.015) | 0.007 (0, 0.012) | 0.007 (0.002, 0.013) | 0.006 (0, 0.013) | NA (NA, NA) | 0 (0, 0.018) | 0 (0, 0.02) | 0 (0, 0) |
| signature | treatment | var | —- | —+ | –+- | –++ | -+– | -+-+ | -++- | -+++ | +— | +–+ | +-+- | +-++ | ++– | ++-+ | +++- | ++++ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| all | TC1 | count | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 | 50 |
| all | TC1 | time | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) | 46 (27, 56) |
| all | TC1 | n | 46 (25, 140) | 12 (7, 26) | 4 (2, 7) | 14 (7, 18) | 22 (9, 52) | 14 (7, 36) | 10 (6, 22) | 8 (5, 16) | 10 (4, 17) | 0 (0, 0) | 8 (4, 12) | 2 (0, 4) | 0 (0, 1) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | post_p | 0.28 (0.04, 0.45) | 0.34 (0.08, 0.45) | 0.4 (0.14, 0.49) | 0.16 (0.03, 0.47) | 0.3 (0.09, 0.44) | 0.32 (0.12, 0.46) | 0.24 (0.06, 0.45) | 0.27 (0.07, 0.45) | 0.34 (0.15, 0.47) | NA (NA, NA) | 0.25 (0.06, 0.45) | 0.43 (0.33, 0.5) | 0.44 (0.42, 0.46) | 0.44 (0.27, 0.49) | NA (NA, NA) | NA (NA, NA) |
| all | TC1 | r_prob | 0.37 (0.37, 0.37) | 0.27 (0.27, 0.27) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC1 | rate | 0.029 (0.024, 0.04) | 0.029 (0.022, 0.049) | 0.036 (0.012, 0.099) | 0.03 (0.016, 0.045) | 0.032 (0.024, 0.048) | 0.029 (0.018, 0.043) | 0.027 (0.02, 0.046) | 0.026 (0.017, 0.052) | 0.031 (0.021, 0.05) | NA (NA, NA) | 0.032 (0.021, 0.056) | 0.035 (0, 0.09) | 0.035 (0, 0.108) | 0.041 (0.014, 0.16) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| all | TC2 | time | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) | 8 (8, 8) |
| all | TC2 | n | 14 (12, 16) | 1 (0, 2) | 2 (2, 2) | 7 (7, 7) | 10 (10, 10) | 7 (5, 9) | 5 (4, 6) | 4 (3, 6) | 2 (2, 2) | 0 (0, 0) | 4 (2, 5) | 0 (0, 1) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | post_p | 0.42 (0.37, 0.47) | 0.43 (0.43, 0.43) | 0.49 (0.49, 0.49) | 0.49 (0.49, 0.5) | 0.37 (0.35, 0.38) | 0.45 (0.44, 0.46) | 0.48 (0.48, 0.48) | 0.48 (0.48, 0.48) | 0.49 (0.48, 0.49) | NA (NA, NA) | 0.48 (0.48, 0.48) | 0.5 (0.5, 0.5) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC2 | r_prob | 0.25 (0.25, 0.25) | 0.07 (0.07, 0.07) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) |
| all | TC2 | rate | 0.039 (0.027, 0.051) | 0.182 (0.182, 0.182) | 0 (0, 0) | 0.017 (0.003, 0.031) | 0.04 (0.04, 0.041) | 0.032 (0.024, 0.041) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | count | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 | 2 |
| all | TC3 | time | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) | 18 (17, 18) |
| all | TC3 | n | 19 (14, 24) | 6 (6, 7) | 0 (0, 1) | 9 (7, 11) | 8 (6, 9) | 4 (3, 5) | 6 (4, 8) | 4 (3, 4) | 12 (10, 14) | 0 (0, 0) | 8 (8, 9) | 2 (1, 4) | 0 (0, 1) | 4 (2, 5) | 0 (0, 0) | 0 (0, 0) |
| all | TC3 | post_p | 0.26 (0.23, 0.3) | 0.37 (0.36, 0.38) | 0.48 (0.48, 0.48) | 0.35 (0.31, 0.39) | 0.49 (0.48, 0.5) | 0.44 (0.43, 0.44) | 0.46 (0.46, 0.46) | 0.44 (0.42, 0.47) | 0.48 (0.46, 0.49) | NA (NA, NA) | 0.43 (0.38, 0.48) | NA (NA, NA) | NA (NA, NA) | 0.49 (0.49, 0.49) | NA (NA, NA) | NA (NA, NA) |
| all | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) |
| all | TC3 | rate | 0.039 (0.038, 0.039) | 0.041 (0.035, 0.046) | 0 (0, 0) | 0.049 (0.033, 0.065) | 0.021 (0.016, 0.025) | 0.087 (0.039, 0.136) | 0.025 (0.017, 0.033) | 0.019 (0.004, 0.034) | 0.012 (0.011, 0.013) | NA (NA, NA) | 0.015 (0.013, 0.018) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | NA (NA, NA) | NA (NA, NA) |
| HRD+ | TC1 | count | 13 | 13 | 13 | 13 | 13 | 13 | 13 | 13 | ||||||||
| HRD+ | TC1 | time | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | 58 (51, 60) | ||||||||
| HRD+ | TC1 | n | 26 (10, 37) | 0 (0, 0) | 14 (8, 35) | 5 (2, 8) | 0 (0, 2) | 3 (3, 8) | 0 (0, 0) | 0 (0, 1) | ||||||||
| HRD+ | TC1 | post_p | 0.39 (0.05, 0.49) | NA (NA, NA) | 0.19 (0.05, 0.39) | 0.44 (0.33, 0.49) | 0.45 (0.42, 0.49) | 0.4 (0.15, 0.47) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC1 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC1 | rate | 0.025 (0.02, 0.038) | NA (NA, NA) | 0.028 (0.022, 0.039) | 0.028 (0.017, 0.038) | 0.037 (0.013, 0.136) | 0.041 (0.023, 0.081) | NA (NA, NA) | 0.019 (0.004, 0.035) | ||||||||
| HRD+ | TC2 | count | 4 | 4 | 4 | 4 | 4 | 4 | 4 | 4 | ||||||||
| HRD+ | TC2 | time | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | 52 (49, 56) | ||||||||
| HRD+ | TC2 | n | 32 (21, 37) | 0 (0, 0) | 18 (16, 27) | 2 (0, 5) | 1 (0, 3) | 2 (1, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | post_p | 0.44 (0.31, 0.47) | NA (NA, NA) | 0.39 (0.23, 0.46) | 0.41 (0.39, 0.48) | 0.44 (0.44, 0.44) | 0.43 (0.38, 0.44) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC2 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC2 | rate | 0.025 (0.022, 0.029) | NA (NA, NA) | 0.019 (0.013, 0.026) | 0.036 (0.015, 0.164) | 0.083 (0.074, 0.091) | 0.175 (0.032, 0.43) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | count | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | ||||||||
| HRD+ | TC4 | time | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | 60 (60, 60) | ||||||||
| HRD+ | TC4 | n | 24 (24, 24) | 0 (0, 0) | 14 (14, 14) | 5 (5, 5) | 0 (0, 0) | 8 (8, 8) | 0 (0, 0) | 0 (0, 0) | ||||||||
| HRD+ | TC4 | post_p | 0.39 (0.39, 0.39) | NA (NA, NA) | 0.01 (0.01, 0.01) | 0.46 (0.46, 0.46) | NA (NA, NA) | 0.23 (0.23, 0.23) | NA (NA, NA) | NA (NA, NA) | ||||||||
| HRD+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| HRD+ | TC4 | rate | 0.028 (0.028, 0.028) | NA (NA, NA) | 0.043 (0.043, 0.043) | 0.009 (0.009, 0.009) | NA (NA, NA) | 0.035 (0.035, 0.035) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | count | 211 | 211 | 211 | 211 | 211 | 211 | 211 | 211 | ||||||||
| TP53+ | TC1 | time | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | 42 (30, 54) | ||||||||
| TP53+ | TC1 | n | 26 (13, 55) | 14 (8, 32) | 12 (6, 25) | 9 (6, 17) | 0 (0, 2) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | post_p | 0.36 (0.13, 0.48) | 0.31 (0.11, 0.47) | 0.28 (0.07, 0.45) | 0.28 (0.07, 0.46) | 0.46 (0.42, 0.49) | 0.45 (0.29, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC1 | rate | 0.029 (0.023, 0.04) | 0.03 (0.021, 0.044) | 0.027 (0.019, 0.044) | 0.028 (0.018, 0.047) | 0.03 (0, 0.15) | 0.032 (0.008, 0.086) | 0 (0, 0) | 0 (0, 0.341) | ||||||||
| TP53+ | TC2 | count | 11 | 11 | 11 | 11 | 11 | 11 | 11 | 11 | ||||||||
| TP53+ | TC2 | time | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | 31 (26, 52) | ||||||||
| TP53+ | TC2 | n | 21 (11, 28) | 15 (9, 18) | 16 (13, 30) | 10 (7, 19) | 0 (0, 1) | 3 (2, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | post_p | 0.27 (0.08, 0.48) | 0.29 (0.13, 0.48) | 0.44 (0.38, 0.5) | 0.42 (0.33, 0.47) | 0.49 (0.49, 0.49) | 0.43 (0.32, 0.46) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC2 | r_prob | 0.41 (0.41, 0.41) | 0.27 (0.27, 0.27) | 0.41 (0.41, 0.41) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC2 | rate | 0.029 (0.025, 0.052) | 0.029 (0.017, 0.042) | 0.017 (0.014, 0.02) | 0.018 (0.013, 0.029) | 0 (0, 0) | 0.029 (0.015, 0.113) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | count | 134 | 134 | 134 | 134 | 134 | 134 | 134 | 134 | ||||||||
| TP53+ | TC3 | time | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | 38 (28, 53) | ||||||||
| TP53+ | TC3 | n | 24 (12, 43) | 12 (7, 28) | 12 (6, 25) | 10 (6, 21) | 0 (0, 2) | 3 (0, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC3 | post_p | 0.38 (0.07, 0.48) | 0.32 (0.1, 0.46) | 0.27 (0.06, 0.46) | 0.27 (0.08, 0.45) | 0.48 (0.44, 0.49) | 0.47 (0.41, 0.5) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC3 | rate | 0.029 (0.022, 0.043) | 0.03 (0.022, 0.055) | 0.029 (0.018, 0.056) | 0.026 (0.018, 0.049) | 0 (0, 0.085) | 0.018 (0, 0.049) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | count | 5 | 5 | 5 | 5 | 5 | 5 | 5 | 5 | ||||||||
| TP53+ | TC4 | time | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | 26 (21, 29) | ||||||||
| TP53+ | TC4 | n | 19 (14, 29) | 13 (10, 16) | 8 (6, 11) | 11 (8, 13) | 0 (0, 2) | 2 (0, 4) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TP53+ | TC4 | post_p | 0.34 (0.16, 0.46) | 0.48 (0.27, 0.49) | 0.35 (0.16, 0.42) | 0.44 (0.31, 0.48) | NA (NA, NA) | 0.47 (0.45, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TP53+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TP53+ | TC4 | rate | 0.029 (0.024, 0.034) | 0.017 (0.01, 0.035) | 0.038 (0.017, 0.055) | 0.022 (0.014, 0.028) | 0 (0, 0) | 0.033 (0.009, 0.04) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | count | 265 | 265 | 265 | 265 | 265 | 265 | 265 | 265 | ||||||||
| TEfus+ | TC1 | time | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | 46 (33, 57) | ||||||||
| TEfus+ | TC1 | n | 5 (2, 10) | 16 (9, 34) | 13 (7, 28) | 11 (6, 22) | 9 (5, 14) | 3 (1, 6) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | post_p | 0.41 (0.17, 0.49) | 0.17 (0.02, 0.43) | 0.3 (0.07, 0.47) | 0.27 (0.07, 0.47) | 0.32 (0.08, 0.47) | 0.44 (0.33, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC1 | r_prob | 0.18 (0.18, 0.18) | 0.07 (0.07, 0.07) | 0.12 (0.12, 0.12) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC1 | rate | 0.031 (0.017, 0.078) | 0.027 (0.018, 0.044) | 0.026 (0.018, 0.044) | 0.027 (0.017, 0.045) | 0.029 (0.017, 0.055) | 0.03 (0, 0.089) | 0 (0, 0.028) | 0.039 (0, 0.392) | ||||||||
| TEfus+ | TC3 | count | 49 | 49 | 49 | 49 | 49 | 49 | 49 | 49 | ||||||||
| TEfus+ | TC3 | time | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | 40 (28, 54) | ||||||||
| TEfus+ | TC3 | n | 5 (2, 8) | 14 (10, 23) | 12 (8, 20) | 10 (6, 18) | 12 (8, 23) | 2 (1, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC3 | post_p | 0.42 (0.29, 0.48) | 0.18 (0.03, 0.37) | 0.28 (0.05, 0.47) | 0.34 (0.12, 0.47) | 0.44 (0.31, 0.49) | 0.46 (0.39, 0.49) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.06 (0.06, 0.06) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | 0.5 (0.5, 0.5) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC3 | rate | 0.035 (0.019, 0.074) | 0.028 (0.017, 0.043) | 0.028 (0.019, 0.048) | 0.026 (0.019, 0.041) | 0.016 (0.009, 0.024) | 0.02 (0, 0.055) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | count | 3 | 3 | 3 | 3 | 3 | 3 | 3 | 3 | ||||||||
| TEfus+ | TC4 | time | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | 39 (23, 46) | ||||||||
| TEfus+ | TC4 | n | 4 (2, 7) | 19 (15, 25) | 8 (4, 10) | 12 (10, 18) | 7 (6, 9) | 3 (3, 5) | 0 (0, 0) | 0 (0, 0) | ||||||||
| TEfus+ | TC4 | post_p | 0.43 (0.2, 0.47) | 0.42 (0.21, 0.42) | 0.37 (0.14, 0.39) | 0.35 (0.35, 0.46) | 0.26 (0.15, 0.42) | 0.46 (0.44, 0.47) | NA (NA, NA) | NA (NA, NA) | ||||||||
| TEfus+ | TC4 | r_prob | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.31 (0.31, 0.31) | 0 (0, 0) | 0.33 (0.33, 0.33) | 0 (0, 0) | 0.33 (0.33, 0.33) | ||||||||
| TEfus+ | TC4 | rate | 0.052 (0.027, 0.07) | 0.022 (0.02, 0.022) | 0.022 (0.019, 0.081) | 0.018 (0.011, 0.026) | 0.031 (0.022, 0.046) | 0.023 (0.016, 0.027) | NA (NA, NA) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | count | 209 | 209 | 209 | 209 | 209 | 209 | 209 | 209 | ||||||||
| PI3K+ | TC1 | time | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | 44 (32, 55) | ||||||||
| PI3K+ | TC1 | n | 14 (8, 28) | 15 (9, 26) | 16 (8, 34) | 10 (6, 19) | 0 (0, 0) | 2 (0, 5) | 3 (1, 7) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | post_p | 0.35 (0.1, 0.48) | 0.17 (0.03, 0.44) | 0.34 (0.12, 0.47) | 0.24 (0.06, 0.46) | NA (NA, NA) | 0.44 (0.34, 0.49) | 0.44 (0.26, 0.49) | NA (NA, NA) | ||||||||
| PI3K+ | TC1 | r_prob | 0.27 (0.27, 0.27) | 0.07 (0.07, 0.07) | 0.07 (0.07, 0.07) | 0.06 (0.06, 0.06) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC1 | rate | 0.028 (0.02, 0.048) | 0.027 (0.018, 0.043) | 0.028 (0.021, 0.043) | 0.027 (0.018, 0.052) | 0.081 (0.081, 0.081) | 0.03 (0, 0.079) | 0.032 (0.015, 0.084) | 0 (0, 0.398) | ||||||||
| PI3K+ | TC2 | count | 8 | 8 | 8 | 8 | 8 | 8 | 8 | 8 | ||||||||
| PI3K+ | TC2 | time | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | 30 (23, 41) | ||||||||
| PI3K+ | TC2 | n | 9 (7, 14) | 17 (9, 24) | 16 (11, 18) | 11 (7, 17) | 0 (0, 0) | 1 (0, 3) | 2 (1, 4) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | post_p | 0.39 (0.05, 0.5) | 0.45 (0.4, 0.48) | 0.27 (0.11, 0.47) | 0.4 (0.3, 0.48) | NA (NA, NA) | 0.47 (0.42, 0.49) | 0.44 (0.36, 0.46) | NA (NA, NA) | ||||||||
| PI3K+ | TC2 | r_prob | 0.07 (0.07, 0.07) | 0.27 (0.27, 0.27) | 0.27 (0.27, 0.27) | 0.25 (0.25, 0.25) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | ||||||||
| PI3K+ | TC2 | rate | 0.029 (0.015, 0.064) | 0.014 (0.012, 0.02) | 0.028 (0.013, 0.038) | 0.023 (0.008, 0.031) | NA (NA, NA) | 0.029 (0, 0.972) | 0.037 (0.029, 0.267) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | count | 85 | 85 | 85 | 85 | 85 | 85 | 85 | 85 | ||||||||
| PI3K+ | TC3 | time | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | 40 (29, 54) | ||||||||
| PI3K+ | TC3 | n | 12 (6, 26) | 15 (9, 23) | 13 (9, 27) | 9 (6, 17) | 0 (0, 0) | 3 (0, 6) | 4 (0, 6) | 0 (0, 0) | ||||||||
| PI3K+ | TC3 | post_p | 0.31 (0.12, 0.47) | 0.14 (0.03, 0.42) | 0.27 (0.06, 0.43) | 0.27 (0.09, 0.45) | NA (NA, NA) | 0.48 (0.42, 0.5) | 0.47 (0.42, 0.5) | NA (NA, NA) | ||||||||
| PI3K+ | TC3 | r_prob | 0 (0, 0) | 0 (0, 0) | 0 (0, 0) | 0.06 (0.06, 0.06) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | 0.33 (0.33, 0.33) | ||||||||
| PI3K+ | TC3 | rate | 0.031 (0.022, 0.049) | 0.032 (0.019, 0.047) | 0.03 (0.021, 0.049) | 0.028 (0.02, 0.052) | NA (NA, NA) | 0.016 (0, 0.058) | 0.016 (0.001, 0.037) | 0 (0, 0) |