Setting description

Several treatments more effective in distinctive signatures: (TC2, TEfus+); (TC3, HRD+); (TC4,PI3K )

Simulations setting

Survival curves (by signature)


PFS distributions (by signature)


Treatment effects (by signature)

signature var Other TC1 TC2 TC3 TC4
all param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.026, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.025, shape = 1.3
all summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 35.8, median = 29.3 mean = 32, median = 26.2 mean = 36.8, median = 30.1
all effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.92, hr = 1.12 af = 0.82, hr = 1.29 af = 0.94, hr = 1.08
HRD+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.024, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.028, shape = 1.3
HRD+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 37.9, median = 31 mean = 78.1, median = 63.8 mean = 32.9, median = 26.9
HRD+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.97, hr = 1.04 af = 2, hr = 0.41 af = 0.84, hr = 1.25
TP53+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.025, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.023, shape = 1.3
TP53+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 37.2, median = 30.4 mean = 30.2, median = 24.7 mean = 39.4, median = 32.2
TP53+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.95, hr = 1.07 af = 0.77, hr = 1.4 af = 1.01, hr = 0.99
TEfus+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.028, shape = 1.3 scale = 0.021, shape = 1.3
TEfus+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 72.6, median = 59.3 mean = 32.8, median = 26.8 mean = 43.2, median = 35.3
TEfus+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.86, hr = 0.45 af = 0.84, hr = 1.25 af = 1.11, hr = 0.88
PI3K+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.023, shape = 1.3 scale = 0.03, shape = 1.3 scale = 0.012, shape = 1.3
PI3K+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 40.6, median = 33.2 mean = 30.7, median = 25.1 mean = 78.4, median = 64
PI3K+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.04, hr = 0.95 af = 0.79, hr = 1.36 af = 2.01, hr = 0.4



Survival curves (by subgroup)


PFS distributions (by subgroup)


Treatment effects (by subgroup)

subtype var Other TC1 TC2 TC3 TC4
—- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
—- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 29.4, median = 24
—- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
—+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
—+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 78.1, median = 63.8
—+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 2, hr = 0.41
–+- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
–+- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 78.1, median = 63.8 mean = 29.4, median = 24 mean = 29.4, median = 24
–+- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 2, hr = 0.41 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
–++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
–++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 29.4, median = 24 mean = 78.1, median = 63.8
–++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 0.75, hr = 1.44 af = 2, hr = 0.41
-+– param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
-+– summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 29.4, median = 24
-+– effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
-+-+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
-+-+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 29.4, median = 24 mean = 78.1, median = 63.8
-+-+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44 af = 2, hr = 0.41
-++- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.031, shape = 1.3
-++- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 78.1, median = 63.8 mean = 29.4, median = 24 mean = 29.4, median = 24
-++- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 2, hr = 0.41 af = 0.75, hr = 1.44 af = 0.75, hr = 1.44
-+++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3
-+++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 29.4, median = 24 mean = 79.9, median = 65.3
-+++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 0.75, hr = 1.44 af = 2.05, hr = 0.39
+— param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+— summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+— effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 0.75, hr = 1.44
+–+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
+–+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
+–+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 2, hr = 0.41
+-+- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+-+- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+-+- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 0.75, hr = 1.44
+-++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
+-++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
+-++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 2, hr = 0.41
++– param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
++– summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 29.4, median = 24
++– effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 0.75, hr = 1.44
++-+ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.031, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
++-+ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 29.4, median = 24 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
++-+ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 0.75, hr = 1.44 af = 2, hr = 0.41 af = 2, hr = 0.41
+++- param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.031, shape = 1.3
+++- summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 29.4, median = 24
+++- effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 0.75, hr = 1.44
++++ param scale = 0.024, shape = 1.3 scale = 0.029, shape = 1.3 scale = 0.013, shape = 1.3 scale = 0.012, shape = 1.3 scale = 0.012, shape = 1.3
++++ summary mean = 39, median = 31.9 mean = 31.9, median = 26.1 mean = 70.5, median = 57.5 mean = 78.1, median = 63.8 mean = 78.1, median = 63.8
++++ effect af = 1, hr = 1 af = 0.82, hr = 1.3 af = 1.8, hr = 0.46 af = 2, hr = 0.41 af = 2, hr = 0.41

Errors and power


graduation (counts and proportions):
TC1 TC2 TC3 TC4
all 4 13 11 34
HRD+ 1 9 332 0
TP53+ 5 22 1 30
TEfus+ 0 320 0 10
PI3K+ 0 10 0 362
TC1 TC2 TC3 TC4
all 0.008 0.026 0.022 0.068
HRD+ 0.002 0.018 0.664 0.000
TP53+ 0.010 0.044 0.002 0.060
TEfus+ 0.000 0.640 0.000 0.020
PI3K+ 0.000 0.020 0.000 0.724
futility (counts and proportions):
TC1 TC2 TC3 TC4
all 50 2 2 0
HRD+ 13 4 0 1
TP53+ 211 11 134 5
TEfus+ 265 0 49 3
PI3K+ 209 8 85 0
TC1 TC2 TC3 TC4
all 0.100 0.004 0.004 0.000
HRD+ 0.026 0.008 0.000 0.002
TP53+ 0.422 0.022 0.268 0.010
TEfus+ 0.530 0.000 0.098 0.006
PI3K+ 0.418 0.016 0.170 0.000
max sample size (counts and proportions):
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0
TC1 TC2 TC3 TC4
all 0 0 0 0
HRD+ 0 0 0 0
TP53+ 0 0 0 0
TEfus+ 0 0 0 0
PI3K+ 0 0 0 0


Operating characteristics

Characteristics Overall TC1 TC2 TC3 TC4
Error signature 0.172 0.02 0.052 0.024 0.086
Error subgroup 0.264 0.02 0.106 0.024 0.144
Power signature 0.958 0.00 0.640 0.664 0.724
Power subgroup 0.978 0.00 0.692 0.688 0.810

Median results at the end of the trial

By signature:
signature var Control TC1 TC2 TC3 TC4
all graduation 0 4 13 11 34
all futility 0 50 2 2 0
all max_n 0 0 0 0 0
all n 651 (605, 699) 274 (168, 397) 296 (194, 411) 267 (188, 386) 276 (165, 391)
all n_unique 651 (605, 699) 274 (168, 397) 296 (194, 411) 267 (188, 386) 276 (165, 391)
all time_trial 60 (60, 60) 60 (57, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
all time_stop NA (NA, NA) 46 (19, 56) 12 (8, 19) 13 (11, 18) 12 (10, 17)
all post_p NA (NA, NA) 0.04 (0, 0.28) 0.95 (0.58, 1) 0.47 (0.11, 0.89) 0.99 (0.83, 1)
all rate 0.023 (0.021, 0.024) 0.028 (0.025, 0.031) 0.02 (0.017, 0.023) 0.024 (0.021, 0.026) 0.019 (0.016, 0.021)
HRD+ graduation 0 1 9 332 0
HRD+ futility 0 13 4 0 1
HRD+ max_n 0 0 0 0 0
HRD+ n 87 (73, 103) 34 (22, 52) 38 (22, 57) 54 (50, 78) 34 (18, 52)
HRD+ n_unique 87 (73, 103) 34 (22, 52) 38 (22, 57) 54 (50, 78) 34 (18, 52)
HRD+ time_trial 60 (60, 60) 60 (60, 60) 60 (60, 60) 49 (38, 60) 60 (60, 60)
HRD+ time_stop NA (NA, NA) 57 (51, 60) 53 (48, 58) 44 (37, 54) 60 (60, 60)
HRD+ post_p NA (NA, NA) 0.19 (0.02, 0.58) 0.67 (0.25, 0.95) 1 (0.98, 1) 0.4 (0.08, 0.81)
HRD+ rate 0.022 (0.018, 0.026) 0.028 (0.021, 0.038) 0.019 (0.014, 0.026) 0.009 (0.006, 0.012) 0.024 (0.017, 0.032)
TP53+ graduation 0 5 22 1 30
TP53+ futility 0 211 11 134 5
TP53+ max_n 0 0 0 0 0
TP53+ n 241 (216, 263) 93 (52, 152) 122 (71, 177) 89 (51, 150) 108 (53, 167)
TP53+ n_unique 241 (216, 263) 93 (52, 152) 122 (71, 177) 89 (51, 150) 108 (53, 167)
TP53+ time_trial 60 (60, 60) 60 (34, 60) 60 (60, 60) 60 (36, 60) 60 (60, 60)
TP53+ time_stop NA (NA, NA) 42 (29, 54) 31 (24, 51) 38 (28, 53) 29 (21, 43)
TP53+ post_p NA (NA, NA) 0.13 (0.01, 0.48) 0.9 (0.46, 1) 0.11 (0.01, 0.48) 0.96 (0.66, 1)
TP53+ rate 0.022 (0.02, 0.025) 0.028 (0.024, 0.033) 0.019 (0.015, 0.023) 0.028 (0.024, 0.034) 0.017 (0.013, 0.021)
TEfus+ graduation 0 0 320 0 10
TEfus+ futility 0 265 0 49 3
TEfus+ max_n 0 0 0 0 0
TEfus+ n 208 (182, 233) 61 (48, 105) 120 (56, 187) 78 (52, 128) 90 (53, 142)
TEfus+ n_unique 208 (182, 233) 61 (48, 105) 120 (56, 187) 78 (52, 128) 90 (53, 142)
TEfus+ time_trial 60 (60, 60) 58 (36, 60) 49 (27, 60) 60 (60, 60) 60 (60, 60)
TEfus+ time_stop NA (NA, NA) 46 (33, 57) 39 (26, 56) 40 (28, 54) 28 (22, 41)
TEfus+ post_p NA (NA, NA) 0.01 (0, 0.14) 1 (0.98, 1) 0.14 (0.01, 0.59) 0.85 (0.42, 0.99)
TEfus+ rate 0.018 (0.016, 0.02) 0.028 (0.023, 0.034) 0.01 (0.008, 0.012) 0.022 (0.018, 0.027) 0.015 (0.012, 0.018)
PI3K+ graduation 0 0 10 0 362
PI3K+ futility 0 209 8 85 0
PI3K+ max_n 0 0 0 0 0
PI3K+ n 224 (198, 249) 76 (50, 129) 110 (60, 164) 81 (50, 138) 108 (54, 195)
PI3K+ n_unique 224 (198, 249) 76 (50, 129) 110 (60, 164) 81 (50, 138) 108 (54, 195)
PI3K+ time_trial 60 (60, 60) 60 (37, 60) 60 (60, 60) 60 (43, 60) 42 (26, 60)
PI3K+ time_stop NA (NA, NA) 44 (32, 55) 32 (23, 53) 40 (29, 54) 36 (25, 52)
PI3K+ post_p NA (NA, NA) 0.08 (0, 0.39) 0.92 (0.59, 1) 0.12 (0.01, 0.49) 1 (1, 1)
PI3K+ rate 0.022 (0.019, 0.024) 0.028 (0.023, 0.034) 0.017 (0.014, 0.021) 0.027 (0.022, 0.032) 0.009 (0.007, 0.011)


By subgroup combinations:
subtype var Control TC1 TC2 TC3 TC4
—- graduation 0 4 13 11 34
—- futility 0 50 2 2 0
—- max_n 0 0 0 0 0
—- n 205 (173, 232) 96 (28, 206) 58 (23, 165) 66 (21, 173) 59 (18, 158)
—- n_unique 205 (173, 232) 96 (28, 206) 58 (23, 165) 66 (21, 173) 59 (18, 158)
—- post_p NA (NA, NA) 0.35 (0.05, 0.81) 0.19 (0.03, 0.62) 0.18 (0.03, 0.66) 0.19 (0.02, 0.61)
—- rate 0.025 (0.022, 0.029) 0.028 (0.023, 0.037) 0.031 (0.025, 0.041) 0.031 (0.025, 0.041) 0.031 (0.025, 0.043)
—+ graduation 0 4 23 11 395
—+ futility 0 226 10 87 0
—+ max_n 0 0 0 0 0
—+ n 47 (36, 57) 17 (8, 39) 16 (7, 38) 15 (7, 36) 24 (9, 46)
—+ n_unique 47 (36, 57) 17 (8, 39) 16 (7, 38) 15 (7, 36) 24 (9, 46)
—+ post_p NA (NA, NA) 0.36 (0.08, 0.74) 0.3 (0.07, 0.68) 0.3 (0.09, 0.7) 0.99 (0.9, 1)
—+ rate 0.026 (0.02, 0.032) 0.029 (0.02, 0.047) 0.03 (0.021, 0.054) 0.031 (0.021, 0.047) 0.009 (0.005, 0.015)
–+- graduation 0 4 333 11 44
–+- futility 0 287 2 51 3
–+- max_n 0 0 0 0 0
–+- n 13 (8, 18) 6 (3, 11) 7 (3, 15) 6 (3, 13) 6 (2, 11)
–+- n_unique 13 (8, 18) 6 (3, 11) 7 (3, 15) 6 (3, 13) 6 (2, 11)
–+- post_p NA (NA, NA) 0.36 (0.12, 0.66) 0.78 (0.5, 0.94) 0.34 (0.1, 0.65) 0.34 (0.12, 0.59)
–+- rate 0.018 (0.009, 0.03) 0.029 (0.014, 0.064) 0.009 (0, 0.02) 0.03 (0.013, 0.063) 0.032 (0.016, 0.07)
–++ graduation 0 4 336 11 398
–++ futility 0 359 10 125 3
–++ max_n 0 0 0 0 0
–++ n 69 (53, 83) 16 (9, 40) 36 (17, 68) 17 (8, 46) 29 (14, 65)
–++ n_unique 69 (53, 83) 16 (9, 40) 36 (17, 68) 17 (8, 46) 29 (14, 65)
–++ post_p NA (NA, NA) 0.11 (0.01, 0.4) 0.95 (0.66, 1) 0.08 (0.01, 0.3) 0.97 (0.74, 1)
–++ rate 0.018 (0.014, 0.023) 0.03 (0.02, 0.046) 0.01 (0.007, 0.015) 0.031 (0.022, 0.049) 0.009 (0.006, 0.014)
-+– graduation 0 9 35 12 64
-+– futility 0 219 13 136 5
-+– max_n 0 0 0 0 0
-+– n 84 (68, 102) 34 (13, 75) 31 (15, 73) 29 (11, 69) 30 (10, 70)
-+– n_unique 84 (68, 102) 34 (13, 75) 31 (15, 73) 29 (11, 69) 30 (10, 70)
-+– post_p NA (NA, NA) 0.38 (0.1, 0.81) 0.3 (0.05, 0.73) 0.3 (0.06, 0.75) 0.31 (0.05, 0.77)
-+– rate 0.025 (0.021, 0.031) 0.029 (0.022, 0.041) 0.031 (0.024, 0.044) 0.031 (0.023, 0.044) 0.03 (0.022, 0.048)
-+-+ graduation 0 7 44 11 403
-+-+ futility 0 303 19 161 3
-+-+ max_n 0 0 0 0 0
-+-+ n 57 (45, 69) 18 (8, 46) 20 (9, 43) 17 (7, 45) 28 (12, 55)
-+-+ n_unique 57 (45, 69) 18 (8, 46) 20 (9, 43) 17 (7, 45) 28 (12, 55)
-+-+ post_p NA (NA, NA) 0.39 (0.09, 0.8) 0.3 (0.06, 0.7) 0.28 (0.06, 0.7) 1 (0.93, 1)
-+-+ rate 0.025 (0.02, 0.032) 0.028 (0.019, 0.044) 0.031 (0.022, 0.047) 0.032 (0.021, 0.047) 0.009 (0.006, 0.014)
-++- graduation 0 7 337 11 71
-++- futility 0 375 10 173 8
-++- max_n 0 0 0 0 0
-++- n 52 (41, 63) 13 (6, 31) 33 (15, 57) 14 (7, 37) 14 (6, 40)
-++- n_unique 52 (41, 63) 13 (6, 31) 33 (15, 57) 14 (7, 37) 14 (6, 40)
-++- post_p NA (NA, NA) 0.18 (0.03, 0.53) 0.98 (0.83, 1) 0.13 (0.02, 0.46) 0.15 (0.02, 0.42)
-++- rate 0.018 (0.013, 0.023) 0.029 (0.02, 0.045) 0.009 (0.005, 0.013) 0.031 (0.021, 0.051) 0.031 (0.021, 0.053)
-+++ graduation 0 7 340 11 404
-+++ futility 0 404 16 195 6
-+++ max_n 0 0 0 0 0
-+++ n 38 (26, 48) 11 (6, 24) 20 (8, 39) 12 (6, 29) 17 (7, 34)
-+++ n_unique 38 (26, 48) 11 (6, 24) 20 (8, 39) 12 (6, 29) 17 (7, 34)
-+++ post_p NA (NA, NA) 0.18 (0.04, 0.5) 0.86 (0.5, 0.98) 0.14 (0.02, 0.41) 0.91 (0.65, 0.99)
-+++ rate 0.018 (0.013, 0.025) 0.029 (0.019, 0.048) 0.01 (0.006, 0.018) 0.031 (0.02, 0.048) 0.009 (0.004, 0.015)
+— graduation 0 5 22 343 34
+— futility 0 63 6 2 1
+— max_n 0 0 0 0 0
+— n 42 (33, 53) 15 (7, 30) 14 (6, 27) 30 (21, 45) 13 (5, 28)
+— n_unique 42 (33, 53) 15 (7, 30) 14 (6, 27) 30 (21, 45) 13 (5, 28)
+— post_p NA (NA, NA) 0.38 (0.08, 0.78) 0.32 (0.07, 0.71) 1 (0.94, 1) 0.31 (0.08, 0.7)
+— rate 0.026 (0.019, 0.033) 0.028 (0.018, 0.051) 0.031 (0.02, 0.05) 0.009 (0.005, 0.013) 0.032 (0.02, 0.053)
+–+ graduation 0 5 32 325 395
+–+ futility 0 231 13 58 1
+–+ max_n 0 0 0 0 0
+–+ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+–+ post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
+–+ rate 0.039 (0, 0.084) 0.081 (0.081, 0.081) 0.063 (0, 1.075) 0.091 (0.066, 0.116) 0 (0, 0)
+-+- graduation 0 4 337 342 44
+-+- futility 0 293 6 41 4
+-+- max_n 0 0 0 0 0
+-+- n 30 (22, 38) 9 (5, 18) 13 (5, 25) 18 (10, 28) 10 (4, 22)
+-+- n_unique 30 (22, 38) 9 (5, 18) 13 (5, 25) 18 (10, 28) 10 (4, 22)
+-+- post_p NA (NA, NA) 0.21 (0.04, 0.54) 0.8 (0.47, 0.96) 0.88 (0.57, 0.98) 0.18 (0.04, 0.47)
+-+- rate 0.018 (0.012, 0.025) 0.03 (0.017, 0.054) 0.01 (0.004, 0.019) 0.009 (0.005, 0.016) 0.032 (0.019, 0.055)
+-++ graduation 0 4 340 324 398
+-++ futility 0 361 13 87 4
+-++ max_n 0 0 0 0 0
+-++ n 6 (2, 10) 3 (1, 6) 3 (0, 6) 3 (1, 7) 3 (0, 6)
+-++ n_unique 6 (2, 10) 3 (1, 6) 3 (0, 6) 3 (1, 7) 3 (0, 6)
+-++ post_p NA (NA, NA) 0.42 (0.27, 0.56) 0.53 (0.42, 0.67) 0.54 (0.41, 0.71) 0.53 (0.42, 0.67)
+-++ rate 0.016 (0, 0.039) 0.028 (0.007, 0.076) 0.009 (0, 0.034) 0.009 (0, 0.031) 0.009 (0, 0.027)
++– graduation 0 10 44 324 64
++– futility 0 224 17 75 6
++– max_n 0 0 0 0 0
++– n 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 2)
++– n_unique 1 (0, 3) 0 (0, 2) 1 (0, 2) 0 (0, 2) 0 (0, 2)
++– post_p NA (NA, NA) 0.49 (0.42, 0.57) 0.5 (0.43, 0.57) 0.54 (0.46, 0.59) 0.48 (0.41, 0.57)
++– rate 0.026 (0, 0.089) 0.028 (0, 0.13) 0.025 (0, 0.108) 0 (0, 0.052) 0.034 (0, 0.155)
++-+ graduation 0 8 53 312 403
++-+ futility 0 306 22 96 4
++-+ max_n 0 0 0 0 0
++-+ n 8 (4, 13) 4 (1, 8) 5 (2, 9) 5 (1, 9) 3 (1, 7)
++-+ n_unique 8 (4, 13) 4 (1, 8) 5 (2, 9) 5 (1, 9) 3 (1, 7)
++-+ post_p NA (NA, NA) 0.42 (0.22, 0.6) 0.43 (0.22, 0.63) 0.65 (0.45, 0.86) 0.62 (0.42, 0.83)
++-+ rate 0.025 (0.01, 0.045) 0.03 (0.011, 0.073) 0.029 (0.011, 0.063) 0.009 (0, 0.025) 0.009 (0, 0.03)
+++- graduation 0 7 341 322 71
+++- futility 0 378 14 104 9
+++- max_n 0 0 0 0 0
+++- n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
+++- post_p NA (NA, NA) NA (NA, NA) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA)
+++- rate 0.105 (0, 0.35) 0 (0, 0.04) 0 (0, 0) 0 (0, 0) 0 (0, 0.07)
++++ graduation 0 7 344 311 404
++++ futility 0 405 19 122 7
++++ max_n 0 0 0 0 0
++++ n 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ n_unique 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
++++ post_p NA (NA, NA) 0.54 (0.54, 0.54) 0.56 (0.56, 0.56) NA (NA, NA) 0.49 (0.48, 0.52)
++++ rate 0 (0, 0.251) 0 (0, 0.112) 0 (0, 0.023) 0 (0, 0.021) 0 (0, 0.023)

Median results over time

Signatures:

Posterior probabilities

Randomization probabilities

PFS rates


Subgroup combinations:

Posterior probabilities

Randomization probabilities

PFS rates

Median results at stop

By signature

Graduation:
signature var TC1 TC2 TC3 TC4
all count 4 13 11 34
all time_stop 12 (10, 15) 14 (10, 19) 12 (11, 17) 12 (10, 17)
all n_trt 77 (67, 101) 93 (68, 137) 65 (51, 79) 62 (52, 90)
all n_control 104 (95, 130) 119 (84, 159) 102 (94, 135) 96 (79, 138)
all post_p 0.95 (0.89, 0.98) 0.92 (0.87, 0.98) 0.94 (0.88, 0.99) 0.92 (0.88, 0.97)
all order 1 (1, 1) 1 (1, 1) 1 (1, 1) 1 (1, 1)
HRD+ count 1 9 332
HRD+ time_stop 47 (47, 47) 53 (50, 58) 44 (37, 54)
HRD+ n_trt 53 (53, 53) 51 (50, 53) 52 (50, 65)
HRD+ n_control 79 (79, 79) 74 (55, 84) 60 (44, 77)
HRD+ post_p 0.93 (0.93, 0.93) 0.98 (0.95, 1) 1 (0.96, 1)
HRD+ order 2 (2, 2) 2 (1.8, 3.4) 2 (1, 3)
TP53+ count 5 22 1 30
TP53+ time_stop 26 (23, 29) 31 (24, 48) 19 (19, 19) 30 (21, 44)
TP53+ n_trt 54 (51, 57) 90 (63, 143) 51 (51, 51) 63 (51, 118)
TP53+ n_control 75 (71, 87) 106 (71, 170) 62 (62, 62) 98 (58, 165)
TP53+ post_p 0.91 (0.9, 0.94) 0.99 (0.9, 1) 0.98 (0.98, 0.98) 0.98 (0.95, 1)
TP53+ order 1 (1, 1.6) 2 (1, 3) 1 (1, 1) 2 (1, 3.1)
TEfus+ count 320 10
TEfus+ time_stop 39 (26, 56) 27 (22, 36)
TEfus+ n_trt 96 (56, 164) 54 (51, 65)
TEfus+ n_control 116 (70, 190) 71 (60, 93)
TEfus+ post_p 1 (0.95, 1) 0.96 (0.93, 0.98)
TEfus+ order 2 (1, 3) 1 (1, 2)
PI3K+ count 10 362
PI3K+ time_stop 37 (28, 54) 36 (25, 52)
PI3K+ n_trt 74 (60, 113) 98 (60, 161)
PI3K+ n_control 114 (83, 205) 112 (67, 183)
PI3K+ post_p 1 (0.93, 1) 1 (0.99, 1)
PI3K+ order 2 (1, 3.1) 1 (1, 3)
Futility:
signature var TC1 TC2 TC3 TC4
all count 50 2 2
all time_stop 46 (27, 56) 8 (8, 8) 18 (17, 18)
all n_trt 175 (120, 290) 57 (57, 57) 82 (74, 91)
all n_control 470 (242, 610) 63 (60, 66) 143 (143, 143)
all post_p 0 (0, 0.02) 0.24 (0.2, 0.29) 0.05 (0.03, 0.08)
all order 2.5 (1, 5) 1 (1, 1) 1 (1, 1)
HRD+ count 13 4 1
HRD+ time_stop 58 (51, 60) 52 (49, 56) 60 (60, 60)
HRD+ n_trt 53 (51, 61) 58 (54, 63) 51 (51, 51)
HRD+ n_control 84 (78, 103) 74 (72, 88) 89 (89, 89)
HRD+ post_p 0.1 (0.01, 0.17) 0.28 (0.16, 0.3) 0.04 (0.04, 0.04)
HRD+ order 3 (1, 4) 3 (2.3, 4.4) 1 (1, 1)
TP53+ count 211 11 134 5
TP53+ time_stop 42 (30, 54) 31 (26, 52) 38 (28, 53) 26 (21, 29)
TP53+ n_trt 69 (51, 116) 65 (57, 84) 63 (50, 100) 52 (50, 63)
TP53+ n_control 157 (93, 214) 114 (67, 200) 135 (90, 197) 90 (56, 108)
TP53+ post_p 0.08 (0.01, 0.21) 0.18 (0.05, 0.26) 0.09 (0.01, 0.21) 0.15 (0.04, 0.3)
TP53+ order 2 (1, 3) 1 (1, 4) 1 (1, 3) 1 (1, 1)
TEfus+ count 265 49 3
TEfus+ time_stop 46 (33, 57) 40 (28, 54) 39 (23, 46)
TEfus+ n_trt 58 (50, 94) 58 (50, 80) 54 (52, 60)
TEfus+ n_control 141 (90, 202) 113 (68, 187) 132 (62, 166)
TEfus+ post_p 0.02 (0, 0.14) 0.04 (0, 0.21) 0.06 (0.03, 0.16)
TEfus+ order 2 (1, 3) 2 (1, 4) 1 (1, 1.8)
PI3K+ count 209 8 85
PI3K+ time_stop 44 (32, 55) 30 (23, 41) 40 (29, 54)
PI3K+ n_trt 63 (51, 96) 54 (51, 63) 56 (50, 87)
PI3K+ n_control 150 (91, 210) 84 (61, 134) 145 (81, 200)
PI3K+ post_p 0.05 (0.01, 0.19) 0.09 (0.04, 0.29) 0.06 (0.01, 0.19)
PI3K+ order 2 (1, 4) 2 (1, 3) 2 (1, 4)


By subgroup combinations

Graduation:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4
all TC1 time 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15) 12 (10, 15)
all TC1 n 32 (26, 42) 8 (7, 10) 2 (0, 5) 8 (6, 11) 8 (7, 13) 4 (3, 5) 4 (2, 4) 4 (3, 5) 5 (3, 7) 0 (0, 0) 2 (0, 4) 1 (0, 1) 0 (0, 0) 0 (0, 1) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.73 (0.61, 0.92) 0.52 (0.51, 0.57) 0.52 (0.52, 0.52) 0.52 (0.51, 0.56) 0.53 (0.51, 0.55) 0.52 (0.51, 0.53) 0.54 (0.51, 0.55) 0.52 (0.51, 0.54) 0.53 (0.51, 0.55) NA (NA, NA) 0.51 (0.5, 0.51) 0.52 (0.52, 0.52) NA (NA, NA) 0.52 (0.51, 0.54) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.007 (0.001, 0.015) 0.014 (0.003, 0.021) 0 (0, 0) 0 (0, 0) 0.007 (0, 0.016) 0 (0, 0) 0 (0, 0) 0 (0, 0.014) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC2 count 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13 13
all TC2 time 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19) 14 (10, 19)
all TC2 n 27 (21, 46) 3 (1, 10) 1 (0, 5) 12 (4, 16) 17 (11, 19) 8 (5, 12) 8 (5, 13) 6 (3, 12) 3 (1, 6) 0 (0, 0) 2 (1, 6) 0 (0, 1) 0 (0, 0) 0 (0, 2) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.64 (0.56, 0.76) 0.52 (0.51, 0.54) 0.53 (0.51, 0.56) 0.56 (0.51, 0.67) 0.56 (0.52, 0.68) 0.54 (0.52, 0.61) 0.55 (0.52, 0.58) 0.54 (0.5, 0.66) 0.52 (0.5, 0.56) NA (NA, NA) 0.52 (0.51, 0.54) 0.52 (0.51, 0.52) NA (NA, NA) 0.53 (0.51, 0.55) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.013 (0.007, 0.018) 0 (0, 0.015) 0 (0, 0.002) 0 (0, 0.005) 0.011 (0, 0.026) 0 (0, 0.018) 0 (0, 0.018) 0 (0, 0) 0 (0, 0.031) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC3 count 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11 11
all TC3 time 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17) 12 (11, 17)
all TC3 n 16 (12, 20) 4 (0, 6) 1 (0, 2) 6 (3, 8) 7 (5, 15) 4 (2, 6) 4 (2, 6) 3 (2, 5) 11 (7, 13) 0 (0, 0) 4 (2, 6) 1 (0, 2) 0 (0, 1) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.62 (0.52, 0.78) 0.53 (0.52, 0.56) 0.52 (0.5, 0.56) 0.54 (0.51, 0.55) 0.55 (0.5, 0.63) 0.54 (0.51, 0.56) 0.52 (0.5, 0.55) 0.52 (0.5, 0.54) 0.58 (0.52, 0.68) NA (NA, NA) 0.54 (0.52, 0.56) 0.51 (0.51, 0.53) NA (NA, NA) 0.53 (0.52, 0.53) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0 (0, 0.024) 0 (0, 0.007) 0 (0, 0) 0 (0, 0) 0 (0, 0.033) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
all TC4 count 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34 34
all TC4 time 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17) 12 (10, 17)
all TC4 n 16 (10, 24) 6 (4, 11) 1 (0, 4) 10 (4, 15) 7 (4, 14) 9 (4, 14) 3 (1, 6) 4 (2, 11) 3 (0, 6) 0 (0, 0) 3 (0, 6) 0 (0, 2) 0 (0, 0) 1 (0, 3) 0 (0, 0) 0 (0, 0)
all TC4 post_p 0.62 (0.53, 0.74) 0.54 (0.51, 0.61) 0.52 (0.51, 0.55) 0.55 (0.52, 0.63) 0.57 (0.52, 0.65) 0.56 (0.51, 0.6) 0.52 (0.5, 0.55) 0.52 (0.5, 0.57) 0.53 (0.51, 0.57) NA (NA, NA) 0.52 (0.5, 0.56) 0.53 (0.52, 0.56) NA (NA, NA) 0.53 (0.5, 0.56) NA (NA, NA) NA (NA, NA)
all TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
all TC4 rate 0.008 (0, 0.021) 0 (0, 0.008) 0 (0, 0) 0 (0, 0.015) 0 (0, 0.022) 0 (0, 0.013) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0.008) NA (NA, NA) 0 (0, 0)
HRD+ TC1 count 1 1 1 1 1 1 1 1
HRD+ TC1 time 47 (47, 47) 47 (47, 47) 47 (47, 47) 47 (47, 47) 47 (47, 47) 47 (47, 47) 47 (47, 47) 47 (47, 47)
HRD+ TC1 n 36 (36, 36) 0 (0, 0) 15 (15, 15) 0 (0, 0) 0 (0, 0) 2 (2, 2) 0 (0, 0) 0 (0, 0)
HRD+ TC1 post_p 0.93 (0.93, 0.93) NA (NA, NA) 0.71 (0.71, 0.71) NA (NA, NA) NA (NA, NA) 0.55 (0.55, 0.55) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.014 (0.014, 0.014) NA (NA, NA) 0.008 (0.008, 0.008) NA (NA, NA) NA (NA, NA) 0.026 (0.026, 0.026) NA (NA, NA) NA (NA, NA)
HRD+ TC2 count 9 9 9 9 9 9 9 9
HRD+ TC2 time 53 (50, 58) 53 (50, 58) 53 (50, 58) 53 (50, 58) 53 (50, 58) 53 (50, 58) 53 (50, 58) 53 (50, 58)
HRD+ TC2 n 21 (13, 26) 0 (0, 0) 22 (12, 24) 5 (3, 6) 1 (0, 3) 6 (4, 9) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.88 (0.71, 0.98) NA (NA, NA) 0.82 (0.76, 0.98) 0.56 (0.51, 0.64) 0.53 (0.53, 0.53) 0.56 (0.52, 0.74) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.016 (0.012, 0.02) NA (NA, NA) 0.007 (0.002, 0.01) 0.008 (0, 0.016) 0.018 (0, 0.034) 0.016 (0.008, 0.023) NA (NA, NA) NA (NA, NA)
HRD+ TC3 count 332 332 332 332 332 332 332 332
HRD+ TC3 time 44 (37, 54) 44 (37, 54) 44 (37, 54) 44 (37, 54) 44 (37, 54) 44 (37, 54) 44 (37, 54) 44 (37, 54)
HRD+ TC3 n 28 (21, 37) 0 (0, 0) 18 (10, 24) 3 (1, 7) 0 (0, 2) 4 (1, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC3 post_p 0.97 (0.81, 1) NA (NA, NA) 0.8 (0.7, 0.95) 0.55 (0.51, 0.64) 0.54 (0.51, 0.57) 0.57 (0.51, 0.73) 0.52 (0.52, 0.52) NA (NA, NA)
HRD+ TC3 r_prob 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
HRD+ TC3 rate 0.008 (0.003, 0.014) 0.061 (0.012, 0.11) 0.007 (0.003, 0.013) 0 (0, 0.016) 0 (0, 0.031) 0.005 (0, 0.02) 0 (0, 0) 0 (0, 0.018)
TP53+ TC1 count 5 5 5 5 5 5 5 5
TP53+ TC1 time 26 (23, 29) 26 (23, 29) 26 (23, 29) 26 (23, 29) 26 (23, 29) 26 (23, 29) 26 (23, 29) 26 (23, 29)
TP53+ TC1 n 22 (15, 25) 9 (4, 17) 10 (8, 18) 8 (6, 11) 0 (0, 1) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.75 (0.71, 0.78) 0.54 (0.53, 0.85) 0.62 (0.52, 0.73) 0.57 (0.54, 0.66) NA (NA, NA) 0.52 (0.51, 0.53) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.015 (0.009, 0.02) 0.006 (0.002, 0.013) 0.009 (0.008, 0.024) 0 (0, 0.012) 0 (0, 0) 0.012 (0, 0.035) NA (NA, NA) NA (NA, NA)
TP53+ TC2 count 22 22 22 22 22 22 22 22
TP53+ TC2 time 31 (24, 48) 31 (24, 48) 31 (24, 48) 31 (24, 48) 31 (24, 48) 31 (24, 48) 31 (24, 48) 31 (24, 48)
TP53+ TC2 n 32 (18, 42) 18 (10, 34) 22 (15, 37) 15 (7, 28) 0 (0, 1) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.78 (0.71, 0.9) 0.73 (0.54, 0.82) 0.87 (0.74, 0.96) 0.75 (0.57, 0.94) 0.53 (0.53, 0.53) 0.53 (0.5, 0.56) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.018 (0.011, 0.024) 0.016 (0.004, 0.022) 0.006 (0.004, 0.011) 0.005 (0, 0.009) 0.039 (0.012, 0.046) 0.008 (0, 0.038) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 1 1 1 1 1 1 1 1
TP53+ TC3 time 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19) 19 (19, 19)
TP53+ TC3 n 16 (16, 16) 13 (13, 13) 8 (8, 8) 9 (9, 9) 2 (2, 2) 3 (3, 3) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.72 (0.72, 0.72) 0.73 (0.73, 0.73) 0.58 (0.58, 0.58) 0.56 (0.56, 0.56) NA (NA, NA) 0.53 (0.53, 0.53) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0 (0, 0) 0 (0, 0) 0.015 (0.015, 0.015) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
TP53+ TC4 count 30 30 30 30 30 30 30 30
TP53+ TC4 time 30 (21, 44) 30 (21, 44) 30 (21, 44) 30 (21, 44) 30 (21, 44) 30 (21, 44) 30 (21, 44) 30 (21, 44)
TP53+ TC4 n 20 (14, 36) 20 (15, 39) 8 (6, 21) 10 (7, 27) 0 (0, 1) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.75 (0.71, 0.86) 0.87 (0.75, 1) 0.56 (0.52, 0.75) 0.71 (0.54, 0.92) 0.54 (0.54, 0.54) 0.53 (0.51, 0.58) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.016 (0.009, 0.023) 0.005 (0, 0.01) 0.013 (0, 0.022) 0.007 (0, 0.016) 0 (0, 0.046) 0 (0, 0.011) NA (NA, NA) 0 (0, 0)
TEfus+ TC2 count 320 320 320 320 320 320 320 320
TEfus+ TC2 time 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56) 39 (26, 56)
TEfus+ TC2 n 6 (3, 12) 31 (17, 56) 26 (15, 46) 18 (8, 31) 10 (5, 22) 3 (0, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 post_p 0.61 (0.52, 0.86) 0.84 (0.71, 0.98) 0.87 (0.72, 0.99) 0.75 (0.56, 0.94) 0.69 (0.52, 0.9) 0.53 (0.51, 0.6) NA (NA, NA) NA (NA, NA)
TEfus+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC2 rate 0.006 (0, 0.018) 0.008 (0.003, 0.013) 0.007 (0.002, 0.013) 0.008 (0, 0.014) 0.007 (0, 0.016) 0 (0, 0.019) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 count 10 10 10 10 10 10 10 10
TEfus+ TC4 time 27 (22, 36) 27 (22, 36) 27 (22, 36) 27 (22, 36) 27 (22, 36) 27 (22, 36) 27 (22, 36) 27 (22, 36)
TEfus+ TC4 n 2 (1, 5) 22 (17, 33) 8 (7, 10) 13 (6, 19) 6 (3, 7) 2 (1, 7) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.53 (0.51, 0.55) 0.76 (0.74, 0.93) 0.57 (0.51, 0.65) 0.67 (0.54, 0.89) 0.52 (0.5, 0.56) 0.53 (0.51, 0.59) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0 (0, 0.002) 0.005 (0, 0.009) 0.015 (0, 0.024) 0.004 (0, 0.009) 0.014 (0, 0.021) 0 (0, 0.001) NA (NA, NA) NA (NA, NA)
PI3K+ TC2 count 10 10 10 10 10 10 10 10
PI3K+ TC2 time 37 (28, 54) 37 (28, 54) 37 (28, 54) 37 (28, 54) 37 (28, 54) 37 (28, 54) 37 (28, 54) 37 (28, 54)
PI3K+ TC2 n 10 (8, 19) 26 (19, 41) 18 (9, 29) 14 (7, 19) 0 (0, 0) 2 (1, 6) 4 (1, 6) 0 (0, 0)
PI3K+ TC2 post_p 0.69 (0.57, 0.87) 0.85 (0.71, 0.94) 0.73 (0.51, 0.82) 0.82 (0.71, 0.92) NA (NA, NA) 0.55 (0.51, 0.67) 0.55 (0.51, 0.62) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.012 (0, 0.018) 0.008 (0.004, 0.01) 0.021 (0.013, 0.027) 0.009 (0, 0.011) NA (NA, NA) 0 (0, 0.008) 0 (0, 0.031) NA (NA, NA)
PI3K+ TC4 count 362 362 362 362 362 362 362 362
PI3K+ TC4 time 36 (25, 52) 36 (25, 52) 36 (25, 52) 36 (25, 52) 36 (25, 52) 36 (25, 52) 36 (25, 52) 36 (25, 52)
PI3K+ TC4 n 21 (10, 37) 26 (16, 48) 26 (15, 45) 16 (8, 29) 0 (0, 0) 2 (0, 6) 3 (1, 6) 0 (0, 0)
PI3K+ TC4 post_p 0.88 (0.7, 1) 0.84 (0.72, 0.98) 0.93 (0.72, 1) 0.75 (0.55, 0.95) NA (NA, NA) 0.53 (0.51, 0.6) 0.55 (0.51, 0.66) 0.51 (0.51, 0.51)
PI3K+ TC4 r_prob 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.31 (0.31, 0.31) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC4 rate 0.008 (0, 0.015) 0.007 (0, 0.012) 0.007 (0.002, 0.013) 0.006 (0, 0.013) NA (NA, NA) 0 (0, 0.018) 0 (0, 0.02) 0 (0, 0)
Futility:
signature treatment var —- —+ –+- –++ -+– -+-+ -++- -+++ +— +–+ +-+- +-++ ++– ++-+ +++- ++++
all TC1 count 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50 50
all TC1 time 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56) 46 (27, 56)
all TC1 n 46 (25, 140) 12 (7, 26) 4 (2, 7) 14 (7, 18) 22 (9, 52) 14 (7, 36) 10 (6, 22) 8 (5, 16) 10 (4, 17) 0 (0, 0) 8 (4, 12) 2 (0, 4) 0 (0, 1) 2 (1, 5) 0 (0, 0) 0 (0, 0)
all TC1 post_p 0.28 (0.04, 0.45) 0.34 (0.08, 0.45) 0.4 (0.14, 0.49) 0.16 (0.03, 0.47) 0.3 (0.09, 0.44) 0.32 (0.12, 0.46) 0.24 (0.06, 0.45) 0.27 (0.07, 0.45) 0.34 (0.15, 0.47) NA (NA, NA) 0.25 (0.06, 0.45) 0.43 (0.33, 0.5) 0.44 (0.42, 0.46) 0.44 (0.27, 0.49) NA (NA, NA) NA (NA, NA)
all TC1 r_prob 0.37 (0.37, 0.37) 0.27 (0.27, 0.27) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC1 rate 0.029 (0.024, 0.04) 0.029 (0.022, 0.049) 0.036 (0.012, 0.099) 0.03 (0.016, 0.045) 0.032 (0.024, 0.048) 0.029 (0.018, 0.043) 0.027 (0.02, 0.046) 0.026 (0.017, 0.052) 0.031 (0.021, 0.05) NA (NA, NA) 0.032 (0.021, 0.056) 0.035 (0, 0.09) 0.035 (0, 0.108) 0.041 (0.014, 0.16) NA (NA, NA) NA (NA, NA)
all TC2 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC2 time 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8) 8 (8, 8)
all TC2 n 14 (12, 16) 1 (0, 2) 2 (2, 2) 7 (7, 7) 10 (10, 10) 7 (5, 9) 5 (4, 6) 4 (3, 6) 2 (2, 2) 0 (0, 0) 4 (2, 5) 0 (0, 1) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 post_p 0.42 (0.37, 0.47) 0.43 (0.43, 0.43) 0.49 (0.49, 0.49) 0.49 (0.49, 0.5) 0.37 (0.35, 0.38) 0.45 (0.44, 0.46) 0.48 (0.48, 0.48) 0.48 (0.48, 0.48) 0.49 (0.48, 0.49) NA (NA, NA) 0.48 (0.48, 0.48) 0.5 (0.5, 0.5) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC2 r_prob 0.25 (0.25, 0.25) 0.07 (0.07, 0.07) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
all TC2 rate 0.039 (0.027, 0.051) 0.182 (0.182, 0.182) 0 (0, 0) 0.017 (0.003, 0.031) 0.04 (0.04, 0.041) 0.032 (0.024, 0.041) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA) NA (NA, NA) NA (NA, NA)
all TC3 count 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2 2
all TC3 time 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18) 18 (17, 18)
all TC3 n 19 (14, 24) 6 (6, 7) 0 (0, 1) 9 (7, 11) 8 (6, 9) 4 (3, 5) 6 (4, 8) 4 (3, 4) 12 (10, 14) 0 (0, 0) 8 (8, 9) 2 (1, 4) 0 (0, 1) 4 (2, 5) 0 (0, 0) 0 (0, 0)
all TC3 post_p 0.26 (0.23, 0.3) 0.37 (0.36, 0.38) 0.48 (0.48, 0.48) 0.35 (0.31, 0.39) 0.49 (0.48, 0.5) 0.44 (0.43, 0.44) 0.46 (0.46, 0.46) 0.44 (0.42, 0.47) 0.48 (0.46, 0.49) NA (NA, NA) 0.43 (0.38, 0.48) NA (NA, NA) NA (NA, NA) 0.49 (0.49, 0.49) NA (NA, NA) NA (NA, NA)
all TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
all TC3 rate 0.039 (0.038, 0.039) 0.041 (0.035, 0.046) 0 (0, 0) 0.049 (0.033, 0.065) 0.021 (0.016, 0.025) 0.087 (0.039, 0.136) 0.025 (0.017, 0.033) 0.019 (0.004, 0.034) 0.012 (0.011, 0.013) NA (NA, NA) 0.015 (0.013, 0.018) 0 (0, 0) 0 (0, 0) 0 (0, 0) NA (NA, NA) NA (NA, NA)
HRD+ TC1 count 13 13 13 13 13 13 13 13
HRD+ TC1 time 58 (51, 60) 58 (51, 60) 58 (51, 60) 58 (51, 60) 58 (51, 60) 58 (51, 60) 58 (51, 60) 58 (51, 60)
HRD+ TC1 n 26 (10, 37) 0 (0, 0) 14 (8, 35) 5 (2, 8) 0 (0, 2) 3 (3, 8) 0 (0, 0) 0 (0, 1)
HRD+ TC1 post_p 0.39 (0.05, 0.49) NA (NA, NA) 0.19 (0.05, 0.39) 0.44 (0.33, 0.49) 0.45 (0.42, 0.49) 0.4 (0.15, 0.47) NA (NA, NA) NA (NA, NA)
HRD+ TC1 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC1 rate 0.025 (0.02, 0.038) NA (NA, NA) 0.028 (0.022, 0.039) 0.028 (0.017, 0.038) 0.037 (0.013, 0.136) 0.041 (0.023, 0.081) NA (NA, NA) 0.019 (0.004, 0.035)
HRD+ TC2 count 4 4 4 4 4 4 4 4
HRD+ TC2 time 52 (49, 56) 52 (49, 56) 52 (49, 56) 52 (49, 56) 52 (49, 56) 52 (49, 56) 52 (49, 56) 52 (49, 56)
HRD+ TC2 n 32 (21, 37) 0 (0, 0) 18 (16, 27) 2 (0, 5) 1 (0, 3) 2 (1, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC2 post_p 0.44 (0.31, 0.47) NA (NA, NA) 0.39 (0.23, 0.46) 0.41 (0.39, 0.48) 0.44 (0.44, 0.44) 0.43 (0.38, 0.44) NA (NA, NA) NA (NA, NA)
HRD+ TC2 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
HRD+ TC2 rate 0.025 (0.022, 0.029) NA (NA, NA) 0.019 (0.013, 0.026) 0.036 (0.015, 0.164) 0.083 (0.074, 0.091) 0.175 (0.032, 0.43) NA (NA, NA) NA (NA, NA)
HRD+ TC4 count 1 1 1 1 1 1 1 1
HRD+ TC4 time 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60) 60 (60, 60)
HRD+ TC4 n 24 (24, 24) 0 (0, 0) 14 (14, 14) 5 (5, 5) 0 (0, 0) 8 (8, 8) 0 (0, 0) 0 (0, 0)
HRD+ TC4 post_p 0.39 (0.39, 0.39) NA (NA, NA) 0.01 (0.01, 0.01) 0.46 (0.46, 0.46) NA (NA, NA) 0.23 (0.23, 0.23) NA (NA, NA) NA (NA, NA)
HRD+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
HRD+ TC4 rate 0.028 (0.028, 0.028) NA (NA, NA) 0.043 (0.043, 0.043) 0.009 (0.009, 0.009) NA (NA, NA) 0.035 (0.035, 0.035) NA (NA, NA) NA (NA, NA)
TP53+ TC1 count 211 211 211 211 211 211 211 211
TP53+ TC1 time 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54) 42 (30, 54)
TP53+ TC1 n 26 (13, 55) 14 (8, 32) 12 (6, 25) 9 (6, 17) 0 (0, 2) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC1 post_p 0.36 (0.13, 0.48) 0.31 (0.11, 0.47) 0.28 (0.07, 0.45) 0.28 (0.07, 0.46) 0.46 (0.42, 0.49) 0.45 (0.29, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC1 rate 0.029 (0.023, 0.04) 0.03 (0.021, 0.044) 0.027 (0.019, 0.044) 0.028 (0.018, 0.047) 0.03 (0, 0.15) 0.032 (0.008, 0.086) 0 (0, 0) 0 (0, 0.341)
TP53+ TC2 count 11 11 11 11 11 11 11 11
TP53+ TC2 time 31 (26, 52) 31 (26, 52) 31 (26, 52) 31 (26, 52) 31 (26, 52) 31 (26, 52) 31 (26, 52) 31 (26, 52)
TP53+ TC2 n 21 (11, 28) 15 (9, 18) 16 (13, 30) 10 (7, 19) 0 (0, 1) 3 (2, 5) 0 (0, 0) 0 (0, 0)
TP53+ TC2 post_p 0.27 (0.08, 0.48) 0.29 (0.13, 0.48) 0.44 (0.38, 0.5) 0.42 (0.33, 0.47) 0.49 (0.49, 0.49) 0.43 (0.32, 0.46) NA (NA, NA) NA (NA, NA)
TP53+ TC2 r_prob 0.41 (0.41, 0.41) 0.27 (0.27, 0.27) 0.41 (0.41, 0.41) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TP53+ TC2 rate 0.029 (0.025, 0.052) 0.029 (0.017, 0.042) 0.017 (0.014, 0.02) 0.018 (0.013, 0.029) 0 (0, 0) 0.029 (0.015, 0.113) NA (NA, NA) NA (NA, NA)
TP53+ TC3 count 134 134 134 134 134 134 134 134
TP53+ TC3 time 38 (28, 53) 38 (28, 53) 38 (28, 53) 38 (28, 53) 38 (28, 53) 38 (28, 53) 38 (28, 53) 38 (28, 53)
TP53+ TC3 n 24 (12, 43) 12 (7, 28) 12 (6, 25) 10 (6, 21) 0 (0, 2) 3 (0, 6) 0 (0, 0) 0 (0, 0)
TP53+ TC3 post_p 0.38 (0.07, 0.48) 0.32 (0.1, 0.46) 0.27 (0.06, 0.46) 0.27 (0.08, 0.45) 0.48 (0.44, 0.49) 0.47 (0.41, 0.5) NA (NA, NA) NA (NA, NA)
TP53+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TP53+ TC3 rate 0.029 (0.022, 0.043) 0.03 (0.022, 0.055) 0.029 (0.018, 0.056) 0.026 (0.018, 0.049) 0 (0, 0.085) 0.018 (0, 0.049) 0 (0, 0) 0 (0, 0)
TP53+ TC4 count 5 5 5 5 5 5 5 5
TP53+ TC4 time 26 (21, 29) 26 (21, 29) 26 (21, 29) 26 (21, 29) 26 (21, 29) 26 (21, 29) 26 (21, 29) 26 (21, 29)
TP53+ TC4 n 19 (14, 29) 13 (10, 16) 8 (6, 11) 11 (8, 13) 0 (0, 2) 2 (0, 4) 0 (0, 0) 0 (0, 0)
TP53+ TC4 post_p 0.34 (0.16, 0.46) 0.48 (0.27, 0.49) 0.35 (0.16, 0.42) 0.44 (0.31, 0.48) NA (NA, NA) 0.47 (0.45, 0.49) NA (NA, NA) NA (NA, NA)
TP53+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TP53+ TC4 rate 0.029 (0.024, 0.034) 0.017 (0.01, 0.035) 0.038 (0.017, 0.055) 0.022 (0.014, 0.028) 0 (0, 0) 0.033 (0.009, 0.04) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 count 265 265 265 265 265 265 265 265
TEfus+ TC1 time 46 (33, 57) 46 (33, 57) 46 (33, 57) 46 (33, 57) 46 (33, 57) 46 (33, 57) 46 (33, 57) 46 (33, 57)
TEfus+ TC1 n 5 (2, 10) 16 (9, 34) 13 (7, 28) 11 (6, 22) 9 (5, 14) 3 (1, 6) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 post_p 0.41 (0.17, 0.49) 0.17 (0.02, 0.43) 0.3 (0.07, 0.47) 0.27 (0.07, 0.47) 0.32 (0.08, 0.47) 0.44 (0.33, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC1 r_prob 0.18 (0.18, 0.18) 0.07 (0.07, 0.07) 0.12 (0.12, 0.12) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
TEfus+ TC1 rate 0.031 (0.017, 0.078) 0.027 (0.018, 0.044) 0.026 (0.018, 0.044) 0.027 (0.017, 0.045) 0.029 (0.017, 0.055) 0.03 (0, 0.089) 0 (0, 0.028) 0.039 (0, 0.392)
TEfus+ TC3 count 49 49 49 49 49 49 49 49
TEfus+ TC3 time 40 (28, 54) 40 (28, 54) 40 (28, 54) 40 (28, 54) 40 (28, 54) 40 (28, 54) 40 (28, 54) 40 (28, 54)
TEfus+ TC3 n 5 (2, 8) 14 (10, 23) 12 (8, 20) 10 (6, 18) 12 (8, 23) 2 (1, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC3 post_p 0.42 (0.29, 0.48) 0.18 (0.03, 0.37) 0.28 (0.05, 0.47) 0.34 (0.12, 0.47) 0.44 (0.31, 0.49) 0.46 (0.39, 0.49) NA (NA, NA) NA (NA, NA)
TEfus+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.06 (0.06, 0.06) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33) 0.5 (0.5, 0.5) 0.33 (0.33, 0.33)
TEfus+ TC3 rate 0.035 (0.019, 0.074) 0.028 (0.017, 0.043) 0.028 (0.019, 0.048) 0.026 (0.019, 0.041) 0.016 (0.009, 0.024) 0.02 (0, 0.055) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 count 3 3 3 3 3 3 3 3
TEfus+ TC4 time 39 (23, 46) 39 (23, 46) 39 (23, 46) 39 (23, 46) 39 (23, 46) 39 (23, 46) 39 (23, 46) 39 (23, 46)
TEfus+ TC4 n 4 (2, 7) 19 (15, 25) 8 (4, 10) 12 (10, 18) 7 (6, 9) 3 (3, 5) 0 (0, 0) 0 (0, 0)
TEfus+ TC4 post_p 0.43 (0.2, 0.47) 0.42 (0.21, 0.42) 0.37 (0.14, 0.39) 0.35 (0.35, 0.46) 0.26 (0.15, 0.42) 0.46 (0.44, 0.47) NA (NA, NA) NA (NA, NA)
TEfus+ TC4 r_prob 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.31 (0.31, 0.31) 0 (0, 0) 0.33 (0.33, 0.33) 0 (0, 0) 0.33 (0.33, 0.33)
TEfus+ TC4 rate 0.052 (0.027, 0.07) 0.022 (0.02, 0.022) 0.022 (0.019, 0.081) 0.018 (0.011, 0.026) 0.031 (0.022, 0.046) 0.023 (0.016, 0.027) NA (NA, NA) NA (NA, NA)
PI3K+ TC1 count 209 209 209 209 209 209 209 209
PI3K+ TC1 time 44 (32, 55) 44 (32, 55) 44 (32, 55) 44 (32, 55) 44 (32, 55) 44 (32, 55) 44 (32, 55) 44 (32, 55)
PI3K+ TC1 n 14 (8, 28) 15 (9, 26) 16 (8, 34) 10 (6, 19) 0 (0, 0) 2 (0, 5) 3 (1, 7) 0 (0, 0)
PI3K+ TC1 post_p 0.35 (0.1, 0.48) 0.17 (0.03, 0.44) 0.34 (0.12, 0.47) 0.24 (0.06, 0.46) NA (NA, NA) 0.44 (0.34, 0.49) 0.44 (0.26, 0.49) NA (NA, NA)
PI3K+ TC1 r_prob 0.27 (0.27, 0.27) 0.07 (0.07, 0.07) 0.07 (0.07, 0.07) 0.06 (0.06, 0.06) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC1 rate 0.028 (0.02, 0.048) 0.027 (0.018, 0.043) 0.028 (0.021, 0.043) 0.027 (0.018, 0.052) 0.081 (0.081, 0.081) 0.03 (0, 0.079) 0.032 (0.015, 0.084) 0 (0, 0.398)
PI3K+ TC2 count 8 8 8 8 8 8 8 8
PI3K+ TC2 time 30 (23, 41) 30 (23, 41) 30 (23, 41) 30 (23, 41) 30 (23, 41) 30 (23, 41) 30 (23, 41) 30 (23, 41)
PI3K+ TC2 n 9 (7, 14) 17 (9, 24) 16 (11, 18) 11 (7, 17) 0 (0, 0) 1 (0, 3) 2 (1, 4) 0 (0, 0)
PI3K+ TC2 post_p 0.39 (0.05, 0.5) 0.45 (0.4, 0.48) 0.27 (0.11, 0.47) 0.4 (0.3, 0.48) NA (NA, NA) 0.47 (0.42, 0.49) 0.44 (0.36, 0.46) NA (NA, NA)
PI3K+ TC2 r_prob 0.07 (0.07, 0.07) 0.27 (0.27, 0.27) 0.27 (0.27, 0.27) 0.25 (0.25, 0.25) 0 (0, 0) 0 (0, 0) 0 (0, 0) 0 (0, 0)
PI3K+ TC2 rate 0.029 (0.015, 0.064) 0.014 (0.012, 0.02) 0.028 (0.013, 0.038) 0.023 (0.008, 0.031) NA (NA, NA) 0.029 (0, 0.972) 0.037 (0.029, 0.267) NA (NA, NA)
PI3K+ TC3 count 85 85 85 85 85 85 85 85
PI3K+ TC3 time 40 (29, 54) 40 (29, 54) 40 (29, 54) 40 (29, 54) 40 (29, 54) 40 (29, 54) 40 (29, 54) 40 (29, 54)
PI3K+ TC3 n 12 (6, 26) 15 (9, 23) 13 (9, 27) 9 (6, 17) 0 (0, 0) 3 (0, 6) 4 (0, 6) 0 (0, 0)
PI3K+ TC3 post_p 0.31 (0.12, 0.47) 0.14 (0.03, 0.42) 0.27 (0.06, 0.43) 0.27 (0.09, 0.45) NA (NA, NA) 0.48 (0.42, 0.5) 0.47 (0.42, 0.5) NA (NA, NA)
PI3K+ TC3 r_prob 0 (0, 0) 0 (0, 0) 0 (0, 0) 0.06 (0.06, 0.06) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33) 0.33 (0.33, 0.33)
PI3K+ TC3 rate 0.031 (0.022, 0.049) 0.032 (0.019, 0.047) 0.03 (0.021, 0.049) 0.028 (0.02, 0.052) NA (NA, NA) 0.016 (0, 0.058) 0.016 (0.001, 0.037) 0 (0, 0)